Publication:
Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence.

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Date

2021-07-27

Authors

Molina-Santiago, Carlos
Vela-Corcia, David
Petras, Daniel
Diaz-Martinez, Luis
Perez-Lorente, Alicia Isabel
Sopeña-Torres, Sara
Pearson, John
Caraballo-Rodriguez, Andres Mauricio
Dorrestein, Pieter C
de-Vicente, Antonio

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Cell Press
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Abstract

Bacterial communities are in a continuous adaptive and evolutionary race for survival. In this work we expand our knowledge on the chemical interplay and specific mutations that modulate the transition from antagonism to co-existence between two plant-beneficial bacteria, Pseudomonas chlororaphis PCL1606 and Bacillus amyloliquefaciens FZB42. We reveal that the bacteriostatic activity of bacillaene produced by Bacillus relies on an interaction with the protein elongation factor FusA of P. chlororaphis and how mutations in this protein lead to tolerance to bacillaene and other protein translation inhibitors. Additionally, we describe how the unspecific tolerance of B. amyloliquefaciens to antimicrobials associated with mutations in the glycerol kinase GlpK is provoked by a decrease of Bacillus cell membrane permeability, among other pleiotropic responses. We conclude that nutrient specialization and mutations in basic biological functions are bacterial adaptive dynamics that lead to the coexistence of two primary competitive bacterial species rather than their mutual eradication.

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MeSH Terms

Adaptation, Physiological
Alleles
Anti-Infective Agents
Bacillus
Bacterial Proteins
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Mutation
Permeability
Pseudomonas

DeCS Terms

Grupos raciales
Nutrientes
Mutación
Glicerol quinasa
Bacterias
Plomo
Permeabilidad de la membrana celular
Pseudomonas chlororaphis
Bacillus
Biosíntesis de proteínas

CIE Terms

Keywords

Bacillus, Pseudomonas, adaptation, antagonism, bacterial interactions, co-existence, evolution, secondary metabolites, Centro Andaluz de Nanomedicina y Biotecnología (BIONAND)

Citation

Molina-Santiago C, Vela-Corcía D, Petras D, Díaz-Martínez L, Pérez-Lorente AI, Sopeña-Torres S, et al. Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence. Cell Rep. 2021 Jul 27;36(4):109449.