RT Journal Article
T1 Chemical interplay and complementary adaptative strategies toggle bacterial antagonism and co-existence.
A1 Molina-Santiago, Carlos
A1 Vela-Corcía, David
A1 Petras, Daniel
A1 Díaz-Martínez, Luis
A1 Pérez-Lorente, Alicia Isabel
A1 Sopeña-Torres, Sara
A1 Pearson, John
A1 Caraballo-Rodríguez, Andrés Mauricio
A1 Dorrestein, Pieter C
A1 de Vicente, Antonio
A1 Romero, Diego
K1 Bacillus
K1 Pseudomonas
K1 adaptation
K1 antagonism
K1 bacterial interactions
K1 co-existence
K1 evolution
K1 secondary metabolites
AB Bacterial communities are in a continuous adaptive and evolutionary race for survival. In this work we expand our knowledge on the chemical interplay and specific mutations that modulate the transition from antagonism to co-existence between two plant-beneficial bacteria, Pseudomonas chlororaphis PCL1606 and Bacillus amyloliquefaciens FZB42. We reveal that the bacteriostatic activity of bacillaene produced by Bacillus relies on an interaction with the protein elongation factor FusA of P. chlororaphis and how mutations in this protein lead to tolerance to bacillaene and other protein translation inhibitors. Additionally, we describe how the unspecific tolerance of B. amyloliquefaciens to antimicrobials associated with mutations in the glycerol kinase GlpK is provoked by a decrease of Bacillus cell membrane permeability, among other pleiotropic responses. We conclude that nutrient specialization and mutations in basic biological functions are bacterial adaptive dynamics that lead to the coexistence of two primary competitive bacterial species rather than their mutual eradication.
YR 2021
FD 2021
LK http://hdl.handle.net/10668/18268
UL http://hdl.handle.net/10668/18268
LA en
DS RISalud
RD Apr 14, 2025