Publication:
Plasmapheresis as treatment for hyperlipidemic pancreatitis.

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Date

2014-02

Authors

Ramírez-Bueno, A
Salazar-Ramírez, C
Cota-Delgado, F
Torre-Prados, M V de la
Valdivielso, P

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Elsevier
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Abstract

BACKGROUND Severe hypertriglyceridemia with an accumulation of chylomicrons and triglyceride figures >1000 mg/dL can cause acute pancreatitis, a potentially fatal complication. The option of rapid reduction in triglyceride concentrations is attractive and possible with plasmapheresis. METHODS We present the results of an analysis of 11 patients admitted to the intensive care unit with severe hypertriglyceridemic pancreatitis and treated with plasmapheresis. The procedure was repeated until serum triglycerides were below 1000 mg/dL. We recorded anthropometric, clinical data as well as final outcome. RESULTS In eight patients a single plasma exchange was sufficient to reduce triglyceride figures <1000 mg/dL. Only three patients died, all with the worst severity indexes and who experienced the longest delay before the procedure. CONCLUSIONS Our results, together with a review of the literature, confirm the need for a randomized clinical trial to compare conventional treatment vs. plasmapheresis in patients with severe hypertriglyceridemic pancreatitis.

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Journal Article;

MeSH Terms

Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Blood Component Removal::Plasmapheresis
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias::Hyperlipidemias
Medical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Acute Disease
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Index
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans

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Keywords

Plasmapheresis, Acute pancreatitis, Hypertriglyceridemic pancreatitis, Severe hypertriglyceridemia, Plasmaféresis, Pancreatitis, Hiperlipidemias, Enfermedad aguda, Índice de severidad de la enfermedad, Resultado del tratamiento

Citation

Ramírez-Bueno A, Salazar-Ramírez C, Cota-Delgado F, Torre-Prados MV de la, Valdivielso P. Plasmapheresis as treatment for hyperlipidemic pancreatitis. Eur. J. Intern. Med.. 2014 ; 25(2):160-3