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Deficits in executive and memory processes in delusional disorder: a case-control study

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Date

2013-08

Authors

Ibáñez-Casas, Inmaculada
Portugal, Enrique de
González, Nieves
McKenney, Kathryn A
Haro, Josep M
Usall, Judith
Pérez-García, Miguel
Cervilla, Jorge A

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Public Library of Science
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Abstract

OBJECTIVE Delusional disorder has been traditionally considered a psychotic syndrome that does not evolve to cognitive deterioration. However, to date, very little empirical research has been done to explore cognitive executive components and memory processes in Delusional Disorder patients. This study will investigate whether patients with delusional disorder are intact in both executive function components (such as flexibility, impulsivity and updating components) and memory processes (such as immediate, short term and long term recall, learning and recognition). METHODS A large sample of patients with delusional disorder (n = 86) and a group of healthy controls (n = 343) were compared with regard to their performance in a broad battery of neuropsychological tests including Trail Making Test, Wisconsin Card Sorting Test, Colour-Word Stroop Test, and Complutense Verbal Learning Test (TAVEC). RESULTS When compared to controls, cases of delusional disorder showed a significantly poorer performance in most cognitive tests. Thus, we demonstrate deficits in flexibility, impulsivity and updating components of executive functions as well as in memory processes. These findings held significant after taking into account sex, age, educational level and premorbid IQ. CONCLUSIONS Our results do not support the traditional notion of patients with delusional disorder being cognitively intact.

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Journal Article; Research Support, Non-U.S. Gov't;

MeSH Terms

Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Age Factors
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies
Medical Subject Headings::Health Care::Population Characteristics::Socioeconomic Factors::Educational Status
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Executive Function
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Mental Recall
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia::Schizophrenia, Paranoid
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Sex Factors
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Verbal Learning
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult

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Keywords

Neuropsychological Tests, Schizophrenia, Paranoid, Mental Recall, Verbal Learning, Pruebas neuropsicológicas, Esquizofrenia paranoide, Recuerdo mental, Aprendizaje verbal, Estudios de casos y controles, Escolaridad, Función Ejecutiva

Citation

Ibáñez-Casas I, Portugal E de, González N, McKenney KA, Haro JM, Usall J, et al. Deficits in executive and memory processes in delusional disorder: a case-control study. PLoS ONE. 2013; 8(7):e67341