Publication:
What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.

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Date

2018-09-04

Authors

Fernandez-Reina, Alberto
Urdiales, Jose Luis
Sanchez-Jimenez, Francisca

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Abstract

Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations.

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MeSH Terms

Histamine
Serotonin
Catecholamines
Biogenic Amines
Nutritional Status

DeCS Terms

Aminoácidos aromáticos
Catecolaminas
Ciencias de la nutrición
Fenómenos fisiológicos
Fisiología

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Keywords

bowel diseases, catecholamines, colon cancer, gastric cancer, gastrointestinal tract, histamine, inflammation, nutrition, polyamines, serotonin

Citation

Fernández-Reina A, Urdiales JL, Sánchez-Jiménez F. What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract. Foods. 2018 Sep 4;7(9):145.