Publication: What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract.
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Identifiers
Date
2018-09-04
Authors
Fernandez-Reina, Alberto
Urdiales, Jose Luis
Sanchez-Jimenez, Francisca
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction. All these physiological effects involve a variety of tissue-specific cellular receptors and signalling pathways, which conforms to a very complex network that is not yet well-characterized. Strong evidence has proved the importance of this group of molecules in the gastrointestinal context, also playing roles in several pathologies. This work is based on the hypothesis that integration of biomedical information helps to reach new translational actions. Thus, the major aim of this work is to combine scientific knowledge on biomolecules, metabolism and physiology of the main B/A-BAs involved in the pathophysiology of the gastrointestinal tract, in order to point out important gaps in information and other facts deserving further research efforts in order to connect molecular information with pathophysiological observations.
Description
MeSH Terms
Histamine
Serotonin
Catecholamines
Biogenic Amines
Nutritional Status
Serotonin
Catecholamines
Biogenic Amines
Nutritional Status
DeCS Terms
Aminoácidos aromáticos
Catecolaminas
Ciencias de la nutrición
Fenómenos fisiológicos
Fisiología
Catecolaminas
Ciencias de la nutrición
Fenómenos fisiológicos
Fisiología
CIE Terms
Keywords
bowel diseases, catecholamines, colon cancer, gastric cancer, gastrointestinal tract, histamine, inflammation, nutrition, polyamines, serotonin
Citation
Fernández-Reina A, Urdiales JL, Sánchez-Jiménez F. What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract. Foods. 2018 Sep 4;7(9):145.