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Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus

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dc.contributor.authorFerrera-Suanzes, Marta
dc.contributor.authorPrieto, Victoria
dc.contributor.authorMedina-Olivera, Antonio J.
dc.contributor.authorBotubol-Ares, José Manuel
dc.contributor.authorGalán-Sánchez, Fátima
dc.contributor.authorRodríguez-Iglesias, Manuel A.
dc.contributor.authorHernández-Galán, Rosario
dc.contributor.authorDurán-Peña, María Jesús
dc.contributor.authoraffiliation[Ferrera-Suanzes,M; Medina-Olivera,AJ; Botubol-Ares,JM; Hernández-Galán,R; Durán-Peña,MJ] Department of Organic Chemistry, Faculty of Sciences, Campus Universitario Río San Pedro, University of Cádiz, Puerto Real, Cádiz, Spain. [Prieto,V; Galán-Sánchez,F; Rodríguez-Iglesias,MA] Department of Biomedicine, Biotechnology and Public Health, Hospital Puerta del Mar, University of Cádiz, Cádiz, Spain. [Galán-Sánchez,F; Rodríguez-Iglesias,MA; Hernández-Galán,R] Instituto de investigación e Innovación Biomédica de Cádiz (INIBICA), Cádiz, Spain.
dc.contributor.funderWe would like to thank the research programme ‘Programa de fomento e impulso de la investigación y la transferencia en la Universidad de Cádiz’ from University of Cádiz for the funding for this project PR2017-046.
dc.date.accessioned2022-10-31T10:20:47Z
dc.date.available2022-10-31T10:20:47Z
dc.date.issued2020-08-06
dc.description.abstractStaphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) have become serious infections in humans and ruminants. S. aureus strains are showing rapid changes to develop resistance in traditional antibiotic-containing systems. In the continuous fierce fight against the emergent multi-drug resistant bacterial strains, straightforward and scalable synthetic procedures to produce new active molecules are in demand. Analysis of molecular properties points to degraded limonoids as promising candidates. In this article, we report a simple synthetic approach to obtain degraded limonoid analogs as scaffolds for new antibacterial molecules. The minimum inhibitory concentrations against S. aureus were evaluated for the stereoisomer mixtures by the broth microdilution method. Analysis of results showed that the acetylated derivatives were the most active of them all.es_ES
dc.description.versionYeses_ES
dc.identifier.citationFerrera-Suanzes M, Prieto V, Medina-Olivera AJ, Botubol-Ares JM, Galán-Sánchez F, Rodríguez-Iglesias MA, et al. Synthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureus. Antibiotics. 2020 Aug 6;9(8):488es_ES
dc.identifier.doi10.3390/antibiotics9080488es_ES
dc.identifier.essn2079-6382
dc.identifier.pmcPMC7459938
dc.identifier.pmid32781770es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4303
dc.journal.titleAntibiotics
dc.language.isoen
dc.page.number16 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/9/8/488/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDegraded limonoidses_ES
dc.subjectDrug designes_ES
dc.subjectS. aureuses_ES
dc.subjectMRSAes_ES
dc.subjectDrug-like propertieses_ES
dc.subjectMethicillin-resistant staphylococcus aureuses_ES
dc.subjectStaphylococcus aureuses_ES
dc.subjectDiseño de fármacoses_ES
dc.subjectStaphylococcus aureus resistente a meticilinaes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureus::Methicillin-Resistant Staphylococcus aureuses_ES
dc.subject.meshMedical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureuses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Triterpenes::Limoninses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Organic Chemistry Phenomena::Isomerism::Stereoisomerismes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Testses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agentses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminantses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.titleSynthesis of Degraded Limonoid Analogs as New Antibacterial Scaffolds against Staphylococcus aureuses_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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