Publication:
INTERGROWTH-21st versus a customized method for the prediction of neonatal nutritional status in hypertensive disorders of pregnancy.

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Date

2022-02-19

Authors

Fernandez-Alba, Juan Jesus
Castillo Lara, Maria
Sanchez Mera, Raquel
Aragon Baizan, Sara
Gonzalez Macias, Carmen
Quintero Prado, Rocio
Vilar Sanchez, Angel
Jimenez Heras, Jose Manuel
Moreno Corral, Luis Javier
Figueras, Francesc

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BioMed Central
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Abstract

Hypertensive disorders of pregnancy (HDP) generate complications and are one of the principal causes of maternal, foetal, and neonatal mortality worldwide. It has been observed that in pregnancies with HDP, the incidence of foetuses small for their gestational age (SGA) is twice as high as that in noncomplicated pregnancies. In women with HDP, the identification of foetuses (SGA) is substantially important, as management and follow-up are determined by this information. The objective of this study was to evaluate whether the INTERGROWTH-21st method or customized birthweight references better identify newborns with an abnormal nutritional status resulting from HDP. A comparative analysis study was designed with two diagnostic methods for the prediction of neonatal nutritional status in pregnancies with HDP. The performance of both methods in identifying neonatal malnutrition (defined by a neonatal body mass index  The study included 226 pregnant women diagnosed with HDP. The customized method identified 45 foetuses as small for gestational age (19.9%), while the INTERGROWTH-21st method identified 27 newborns with SGA (11.9%). The difference between proportions was statistically significant (p  In pregnant women with HDP, the predictive ability of the customized foetal growth curves to identify neonatal malnutrition appears to surpass that of INTERGROWTH-21st.

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MeSH Terms

Birth weight
Female
Fetal development
Humans
Hypertension, pregnancy-induced
Infant nutrition disorders
Infant, newborn
Infant, small for gestational age
Nutritional status
Odds ratio
Predictive value of tests
Pregnancy
Reference standards
Reference values
Sensitivity and specificity
Spain

DeCS Terms

Desarrollo fetal
Embarazo
Estado nutricional
Hipertensión inducida en el embarazo
Recién nacido
Sensibilidad y especificidad
Valor predictivo de las pruebas
Valores de referencia

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Keywords

Foetal growth, Foetal malnutrition, Gestational hypertension, Hypertensive disorders of pregnancy, Small for gestational age (SGA)

Citation

Fernández-Alba JJ, Castillo Lara M, Sánchez Mera R, Aragón Baizán S, González Macías C, Quintero Prado R, et al. INTERGROWTH-21st versus a customized method for the prediction of neonatal nutritional status in hypertensive disorders of pregnancy. BMC Pregnancy Childbirth. 2022 Feb 19;22(1):136