Publication:
D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats.

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Date

2020-07-08

Authors

Navarro, Juan A
Decara, Juan
Medina-Vera, Dina
Tovar, Rubén
Suarez, Juan
Pavón, Javier
Serrano, Antonia
Vida, Margarita
Gutierrez-Adan, Alfonso
Sanjuan, Carlos

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Abstract

To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.

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MeSH Terms

Administration, Oral
Animals
Depression, Chemical
Fabaceae
Ghrelin
Glucagon
Glycogen
Glycogen Synthase Kinase 3
Glycolysis
Inositol
Insulin Secretion
Liver
Male
Phosphorylation
Proto-Oncogene Proteins c-akt
Pyruvate Kinase
Rats, Wistar

DeCS Terms

Adiponectina
Fosforilación
Glucólisis
Hormonas
Secreción de insulina
Metabolismo

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Keywords

AKT, D-Pinitol, ghrelin, insulin, insulin resistance, liver, phosphorylation

Citation

Navarro JA, Decara J, Medina-Vera D, Tovar R, Suarez J, Pavón J, et al. D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. Nutrients. 2020 Jul 8;12(7):2030