RT Journal Article
T1 D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats.
A1 Navarro, Juan A
A1 Decara, Juan
A1 Medina-Vera, Dina
A1 Tovar, Rubén
A1 Suarez, Juan
A1 Pavón, Javier
A1 Serrano, Antonia
A1 Vida, Margarita
A1 Gutierrez-Adan, Alfonso
A1 Sanjuan, Carlos
A1 Baixeras, Elena
A1 Fonseca, Fernando Rodríguez de
A2 https://www.mdpi.com/2072-6643/12/7/2030, 
K1 AKT
K1 D-Pinitol
K1 ghrelin
K1 insulin
K1 insulin resistance
K1 liver
K1 phosphorylation
AB To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.
YR 2020
FD 2020-07-08
LK http://hdl.handle.net/10668/15920
UL http://hdl.handle.net/10668/15920
LA en
NO Navarro JA, Decara J, Medina-Vera D, Tovar R, Suarez J, Pavón J, et al. D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. Nutrients. 2020 Jul 8;12(7):2030
NO The present study was supported by grants from the following institutions: Ministerio de Economía y Competitividad, Gobierno de España, (Grant RTC-2016-4983-1), EU-ERDF-Instituto de Salud Carlos III (Grant PI19/01577), EULAC-HEALTH Fatzheimer (Grant AC17/00112) and Consejería de Economía, Conocimiento y Universidad, Junta de Andalucía (Grant P18-TP-5194).
DS RISalud
RD Apr 8, 2025