Publication:
Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study

dc.contributor.authorFernández-Cidón, Bárbara
dc.contributor.authorCandás-Estébanez, Beatriz
dc.contributor.authorGil-Serret, Miriam
dc.contributor.authorAmigó, Núria
dc.contributor.authorCorbella, Emili
dc.contributor.authorRodríguez-Sánchez, M. Ángeles
dc.contributor.authorPadró-Miquel, Ariadna
dc.contributor.authorBrotons, Carlos
dc.contributor.authorHernández-Mijares, Antonio
dc.contributor.authorCalmarza, Pilar
dc.contributor.authorJarauta, Estibaliz
dc.contributor.authorBrea, Angel J.
dc.contributor.authorMauri, Marta
dc.contributor.authorGuijarro, Carlos
dc.contributor.authorVila, Àlex
dc.contributor.authorValdivielso, Pedro
dc.contributor.authorCorbella, Xavier
dc.contributor.authorPintó, Xavier
dc.contributor.authoraffiliation[Fernández-Cidón,B; Candás-Estébanez,B; Padró-Miquel,A] Bioquímica Especial y Biología Molecular, Laboratori Clínic, Hospital Universitario de Bellvitge, L’Hospitalet de Ll., Spain. [Candás-Estébanez,B] Clinical Laboratory, SCIAS-Hospital de Barcelona, Barcelona, Spain. [Gil-Serret,M; Amigó,N] Biosfer Teslab, Reus, Spain. [Amigó,N] CIBERDEM, Universidad Rovira i Virgili, Tarragona, Spain. [Corbella,E; Rodríguez-Sánchez,MA; Corbella,X; Pintó,X] Unidad de Lípidos y Riesgo Vascular, Servicio de Medicina Interna, Hospital Universitario de Bellvitge-IDIBELL, Barcelona, Spain. [Corbella,E; Pintó,X] Centro de Investigación Biomédica en Red, Fisiopatologia de la Obesidad y Nutrición CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [Brotons,C] EAP Sardenya, Instituto de Investigaciones Biomédicas Sant Pau, Barcelona, Spain. [Hernández-Mijares,A] Hospital Universitario Dr. Peset, Valencia, Spain. [Calmarza,P; Jarauta,E] Servicio de Bioquímica Clínica, Hospital Universitario Miguel Servet, CIBERCV IIS Aragón, Universidad de Zaragoza, Zaragoza, Spain. [Brea,AJ] Hospital General San Pedro, Logroño, Spain. [Mauri,M] Hospital de Terrassa (Consorci Sanitari de Terrassa), Terrassa, Spain. [Guijarro,C] Departamento de Esepecialidades Médicas y Salud Pública, Unidad de Medicina Interna, Hospital Universitario Fundación Alcorcón, Universidad Rey Juan Carlos, Alcorcón, Spain. [Vila,A] Hospital de Figueres (Fundació Salut Empordà), Figueres, Spain. [Valdivielso,P] Hospital Universitario Virgen de la Victoria, IBIMA, Universidad de Málaga, Málaga, Spain. [Corbella,X] Facultad de Medicina y Ciencias de la Salud, Universitat Internacional de Catalunya, Barcelona, Spain. [Pintó,X] Department of Medicine, Campus Bellvitge, Universidad de Barcelona, L’Hospitalet de Ll., Spain.
dc.contributor.funderThis work was supported in part by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund, funded by the following grant codes: PI16/01094 and PI19/01032.
dc.date.accessioned2023-01-16T11:53:00Z
dc.date.available2023-01-16T11:53:00Z
dc.date.issued2021-03-29
dc.description.abstractSome lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.es_ES
dc.description.versionYeses_ES
dc.identifier.citationFernández-Cidón B, Candás-Estébanez B, Gil-Serret M, Amigó N, Corbella E, Rodríguez-Sánchez MÁ, et al. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study. J Clin Med. 2021 Mar 29;10(7):1379es_ES
dc.identifier.doi10.3390/jcm10071379es_ES
dc.identifier.essn2077-0383
dc.identifier.pmcPMC8037702
dc.identifier.pmid33805580es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4588
dc.journal.titleJournal of Clinical Medicine
dc.language.isoen
dc.page.number10 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2077-0383/10/7/1379es_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectNMR analysis of lipoproteinses_ES
dc.subjectLipid profilees_ES
dc.subjectPremature cardiovascular diseasees_ES
dc.subjectResidual cardiovascular riskes_ES
dc.subjectSmall dense LDLes_ES
dc.subjectLipoprotein particle numberes_ES
dc.subjectLipoprotein precipitationes_ES
dc.subjectTriglycerideses_ES
dc.subjectAtherosclerosises_ES
dc.subjectLípidoses_ES
dc.subjectEnfermedades cardiovasculareses_ES
dc.subjectFactores de riesgo de enfermedad cardiacaes_ES
dc.subjectLDL-colesteroles_ES
dc.subjectLipoproteínases_ES
dc.subjectTriglycéridoses_ES
dc.subjectAterosclerosises_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL::Cholesterol, LDLes_ES
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseaseses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studieses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Modelses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerideses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteinses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, VLDLes_ES
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosises_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaginges_ES
dc.titlePhysicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Studyes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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