Publication: Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study
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Identifiers
Date
2021-03-29
Authors
Fernández-Cidón, Bárbara
Candás-Estébanez, Beatriz
Gil-Serret, Miriam
Amigó, Núria
Corbella, Emili
Rodríguez-Sánchez, M. Ángeles
Padró-Miquel, Ariadna
Brotons, Carlos
Hernández-Mijares, Antonio
Calmarza, Pilar
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Some lipoprotein disorders related to the residual risk of premature cardiovascular disease (PCVD) are not detected by the conventional lipid profile. In this case-control study, the predictive power of PCVD of serum sdLDL-C, measured using a lipoprotein precipitation method, and of the physicochemical properties of serum lipoproteins, analyzed by nuclear magnetic resonance (NMR) techniques, were evaluated. We studied a group of patients with a first PCVD event (n = 125) and a group of control subjects (n = 190). Conventional lipid profile, the size and number of Very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL) particles, and the number of particles of their subclasses (large, medium, and small) were measured. Compared to controls, PCVD patients had lower concentrations of all LDL particles, and smaller and larger diameter of LDL and HDL particles, respectively. PCVD patients also showed higher concentrations of small dense LDL-cholesterol (sdLDL), and triglycerides (Tg) in LDL and HDL particles (HDL-Tg), and higher concentrations of large VLDL particles. Multivariate logistic regression showed that sdLDL-C, HDL-Tg, and large concentrations of LDL particles were the most powerful predictors of PCVD. A strong relationship was observed between increased HDL-Tg concentrations and PCVD. This study demonstrates that beyond the conventional lipid profile, PCVD patients have other atherogenic lipoprotein alterations that are detected by magnetic resonance imaging (MRI) analysis.
Description
MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL::Cholesterol, LDL
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models
Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerides
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, VLDL
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL::Cholesterol, LDL
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Logistic Models
Medical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerides
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, VLDL
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
DeCS Terms
CIE Terms
Keywords
NMR analysis of lipoproteins, Lipid profile, Premature cardiovascular disease, Residual cardiovascular risk, Small dense LDL, Lipoprotein particle number, Lipoprotein precipitation, Triglycerides, Atherosclerosis, Lípidos, Enfermedades cardiovasculares, Factores de riesgo de enfermedad cardiaca, LDL-colesterol, Lipoproteínas, Triglycéridos, Aterosclerosis
Citation
Fernández-Cidón B, Candás-Estébanez B, Gil-Serret M, Amigó N, Corbella E, Rodríguez-Sánchez MÁ, et al. Physicochemical Properties of Lipoproteins Assessed by Nuclear Magnetic Resonance as a Predictor of Premature Cardiovascular Disease. PRESARV-SEA Study. J Clin Med. 2021 Mar 29;10(7):1379