Publication:
Metabolic Reprogramming in Tumor Endothelial Cells.

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Date

2022-09-17

Authors

Garcia-Caballero, Melissa
Sokol, Liliana
Cuypers, Anne
Carmeliet, Peter

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MDPI
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Abstract

The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer.

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MeSH Terms

Endothelial cells
Humans
Immunotherapy
Neoplasms
Neovascularization, pathologic
Tumor microenvironment

DeCS Terms

Células endoteliales
Humanos
Inmunoterapia
Microambiente tumoral
Neoplasias
Neovascularización patológica

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Keywords

metabolic reprogramming, tumor angiogenesis, tumor endothelial cell metabolism, tumor microenvironment

Citation

García-Caballero M, Sokol L, Cuypers A, Carmeliet P. Metabolic Reprogramming in Tumor Endothelial Cells. Int J Mol Sci. 2022 Sep 21;23(19):11052