Publication: Metabolic Reprogramming in Tumor Endothelial Cells.
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Identifiers
Date
2022-09-17
Authors
Garcia-Caballero, Melissa
Sokol, Liliana
Cuypers, Anne
Carmeliet, Peter
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer.
Description
MeSH Terms
Endothelial cells
Humans
Immunotherapy
Neoplasms
Neovascularization, pathologic
Tumor microenvironment
Humans
Immunotherapy
Neoplasms
Neovascularization, pathologic
Tumor microenvironment
DeCS Terms
Células endoteliales
Humanos
Inmunoterapia
Microambiente tumoral
Neoplasias
Neovascularización patológica
Humanos
Inmunoterapia
Microambiente tumoral
Neoplasias
Neovascularización patológica
CIE Terms
Keywords
metabolic reprogramming, tumor angiogenesis, tumor endothelial cell metabolism, tumor microenvironment
Citation
García-Caballero M, Sokol L, Cuypers A, Carmeliet P. Metabolic Reprogramming in Tumor Endothelial Cells. Int J Mol Sci. 2022 Sep 21;23(19):11052