RT Journal Article
T1 Metabolic Reprogramming in Tumor Endothelial Cells.
A1 Garcia-Caballero, Melissa
A1 Sokol, Liliana
A1 Cuypers, Anne
A1 Carmeliet, Peter
K1 metabolic reprogramming
K1 tumor angiogenesis
K1 tumor endothelial cell metabolism
K1 tumor microenvironment
AB The dynamic crosstalk between the different components of the tumor microenvironment is critical to determine cancer progression, metastatic dissemination, tumor immunity, and therapeutic responses. Angiogenesis is critical for tumor growth, and abnormal blood vessels contribute to hypoxia and acidosis in the tumor microenvironment. In this hostile environment, cancer and stromal cells have the ability to alter their metabolism in order to support the high energetic demands and favor rapid tumor proliferation. Recent advances have shown that tumor endothelial cell metabolism is reprogrammed, and that targeting endothelial metabolic pathways impacts developmental and pathological vessel sprouting. Therefore, the use of metabolic antiangiogenic therapies to normalize the blood vasculature, in combination with immunotherapies, offers a clinical niche to treat cancer.
PB MDPI
YR 2022
FD 2022-09-17
LK http://hdl.handle.net/10668/21199
UL http://hdl.handle.net/10668/21199
LA en
NO García-Caballero M, Sokol L, Cuypers A, Carmeliet P. Metabolic Reprogramming in Tumor Endothelial Cells. Int J Mol Sci. 2022 Sep 21;23(19):11052
DS RISalud
RD Apr 11, 2025