Publication: Nutrition and cellular senescence in obesity-related disorders.
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Identifiers
Date
2021-08-10
Authors
Rubio-Tomas, Teresa
Rueda-Robles, Ascension
Plaza-Diaz, Julio
Alvarez-Mercado, Ana I
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Inc.
Abstract
Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence.
Description
MeSH Terms
Animals
Cellular Senescence
Diet
Humans
Inflammation
Obesity
Cellular Senescence
Diet
Humans
Inflammation
Obesity
DeCS Terms
Senescencia celular
Obesidad
Inflamación
Dieta
Humanos
Obesidad
Inflamación
Dieta
Humanos
CIE Terms
Keywords
aging, diet, inflammation, microbiota obesity, senescence
Citation
Rubio-Tomás T, Rueda-Robles A, Plaza-Díaz J, Álvarez-Mercado AI. Nutrition and cellular senescence in obesity-related disorders. J Nutr Biochem. 2022 Jan;99:108861