RT Journal Article
T1 Nutrition and cellular senescence in obesity-related disorders.
A1 Rubio-Tomas, Teresa
A1 Rueda-Robles, Ascension
A1 Plaza-Diaz, Julio
A1 Alvarez-Mercado, Ana I
K1 aging
K1 diet
K1 inflammation
K1 microbiota obesity
K1 senescence
AB Adequate nutrition is vital for immune homeostasis. However, the incidence of obesity is increasing worldwide due to the adoption of the Western diet and a sedentary lifestyle. Obesity is associated with chronic inflammation which alters the function of adipose tissue, liver, pancreas, and the nervous system. Inflammation is related to cellular senescence, distinguished by irreversible cell cycle arrest. Senescent cells secrete the senescence-associated secretory phenotype (SASP) which contains pro-inflammatory factors. Targeting processes in senescence might have a salutary approach to obesity. The present review highlights the impact of an unhealthy diet on tissues affected by obesity, and the mechanisms that promote the consequent inflammation and senescence.
PB Elsevier Inc.
YR 2021
FD 2021-08-10
LK http://hdl.handle.net/10668/22324
UL http://hdl.handle.net/10668/22324
LA en
NO Rubio-Tomás T, Rueda-Robles A, Plaza-Díaz J, Álvarez-Mercado AI. Nutrition and cellular senescence in obesity-related disorders. J Nutr Biochem. 2022 Jan;99:108861
DS RISalud
RD Apr 18, 2025