Publication:
Blood Pressure Monitoring and Perinatal Outcomes in Normotensive Women with Gestational Diabetes Mellitus.

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Date

2022-03-04

Authors

Lara-Barea, Almudena
Sanchez-Lechuga, Begoña
Vidal-Suárez, Alvaro
Arroba, Ana I
Bugatto, Fernando
Lopez-Tinoco, Cristina

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MDPI
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Abstract

Alterations in ambulatory blood pressure detected by monitoring (ABPM) have been associated with perinatal complications in hypertensive pregnant women. To establish the relationships between the blood pressure (BP) profiles detected by ABPM and adverse perinatal outcomes in normotensive women with gestational diabetes mellitus (GDM). A prospective study of normotensive women in whom 24 h ABPM was performed at 28-32 weeks of pregnancy. The obstetric and perinatal outcomes were evaluated. Two hundred patients were included. Thirty-seven women with GDM and obesity had significantly higher mean systolic BP (SBP) and nocturnal SBP and diastolic BP (DBP) compared to women with only GDM (n = 86). Nocturnal SBP (OR = 1.077; p = 0.015) and obesity (OR = 1.131; p = 0.035) were risk factors for the development of hypertensive disorders of pregnancy (HDPs). Mothers of newborns with neonatal complications (n = 27) had higher nocturnal SBP (103.8 vs. 100 mmHg; p = 0.047) and DBP (62.7 vs. 59.4; p = 0.016). Women who delivered preterm (n = 10) had higher BP and a non-dipper pattern (p = 0.005). Nocturnal SBP was a predictor of HDPs in normotensive women with obesity or GDM. Alterations in ABPM in these patients were associated with poor obstetric and perinatal outcomes.

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MeSH Terms

Infant, Newborn
Pregnancy
Blood Pressure
Diabetes, Gestational
Hypertension, Pregnancy-Induced
Blood Pressure Monitoring, Ambulatory
Pregnant Women
Obesity
Obesidad

DeCS Terms

Diabetes gestacional
Embarazo
Hipertension inducida en el embarazo
Monitoreo ambulatorio de la presion arterial
Mujeres embarazadas
Presion sanguinea
Recien nacido

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Keywords

Ambulatory blood pressure monitoring, Gestational diabetes mellitus, Hypertensive disorders of pregnancy, Perinatal outcomes

Citation

Lara-Barea A, Sánchez-Lechuga B, Vidal-Suárez Á, Arroba AI, Bugatto F, López-Tinoco C. Blood Pressure Monitoring and Perinatal Outcomes in Normotensive Women with Gestational Diabetes Mellitus. J Clin Med. 2022 Mar 5;11(5):1435