Publication:
Relapse or reinfection after failing hepatitis C direct acting antiviral treatment: Unravelled by phylogenetic analysis.

dc.contributor.authorCuypers, Lize
dc.contributor.authorPérez, Ana Belén
dc.contributor.authorChueca, Natalia
dc.contributor.authorAldamiz-Echevarría, Teresa
dc.contributor.authorAlados, Juan Carlos
dc.contributor.authorMartínez-Sapiña, Ana María
dc.contributor.authorMerino, Dolores
dc.contributor.authorPineda, Juan Antonio
dc.contributor.authorTéllez, Francisco
dc.contributor.authorEspinosa, Nuria
dc.contributor.authorSalméron, Javier
dc.contributor.authorRivero-Juarez, Antonio
dc.contributor.authorVivancos, María Jesús
dc.contributor.authorHontañón, Víctor
dc.contributor.authorVandamme, Anne-Mieke
dc.contributor.authorGarcía, Féderico
dc.date.accessioned2023-01-25T10:21:04Z
dc.date.available2023-01-25T10:21:04Z
dc.date.issued2018-07-25
dc.description.abstractDespite high response rates associated to hepatitis C virus (HCV) treatment, no protective immunity is acquired, allowing for reinfection and continued infectiousness. Distinguishing between relapse and reinfection is crucial for patient counselling and to choose the most appropriate retreatment. Here, refined phylogenetic analysis using multiple genes served to assess genotype and reinfection for 53 patients for whom the virus was sampled before start of therapy and at time of sustained virological response evaluation at week 12. At baseline, genotypes were determined as HCV1a (41.5%), HCV1b (24.5%), HCV4 (18.9%) and HCV3a (15.1%), while six cases revealed to be discordantly assigned by phylogeny and commercial assays. Overall, 60.4% was co-infected with HIV. The large majority was classified as people who inject drugs (78.6%), often co-infected with HIV. Transmission was sexual in seven cases, of which five in HIV-positive men-who-have-sex-with-men. Overall, relapse was defined for 44 patients, while no conclusion was drawn for four patients. Five patients were reinfected with a different HCV strain, of which three with a different genotype, showing that phylogeny is needed not only to determine the genotype, but also to distinguish between relapse and intra-subtype reinfection. Of note, phylogenies are more reliable when longer fragments of the viral genome are being sequenced.
dc.identifier.doi10.1371/journal.pone.0201268
dc.identifier.essn1932-6203
dc.identifier.pmcPMC6059487
dc.identifier.pmid30044871
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059487/pdf
dc.identifier.unpaywallURLhttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0201268&type=printable
dc.identifier.urihttp://hdl.handle.net/10668/12754
dc.issue.number7
dc.journal.titlePloS one
dc.journal.titleabbreviationPLoS One
dc.language.isoen
dc.organizationÁrea de Gestión Sanitaria Campo de Gibraltar Oeste
dc.organizationÁrea de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.organizationHospital Universitario Reina Sofía
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Infanta Elena
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationÁrea de Gestión Sanitaria Sur de Sevilla
dc.organizationAGS - Campo de Gibraltar Oeste
dc.organizationAGS - Jerez, Costa Noroeste y Sierra de Cáidz
dc.organizationAGS - Sur de Sevilla
dc.page.numbere0201268
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshAntiviral Agents
dc.subject.meshCoinfection
dc.subject.meshGenome, Viral
dc.subject.meshHIV Infections
dc.subject.meshHepatitis C
dc.subject.meshHepatitis C, Chronic
dc.subject.meshHomosexuality, Male
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPhylogeny
dc.subject.meshRecurrence
dc.titleRelapse or reinfection after failing hepatitis C direct acting antiviral treatment: Unravelled by phylogenetic analysis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
PMC6059487.pdf
Size:
1.22 MB
Format:
Adobe Portable Document Format