Publication:
An update on the implications of cyclin D1 in melanomas.

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Date

2020-03-20

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González-Ruiz, Lucia
González-Moles, Miguel Ángel
González-Ruiz, Isabel
Ruiz-Ávila, Isabel
Ayén, Ángela
Ramos-García, Pablo

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Abstract

Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.

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MeSH Terms

Animals
Biomarkers, Tumor
Cyclin D1
Humans
Melanocytes
Melanoma
Molecular Targeted Therapy
Skin Neoplasms

DeCS Terms

Ciclo celular
Melanoma
Oncogenes
Proteínas Reguladoras del Ciclo Celular
Vías de Señalización Celular

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Keywords

CCND1, cyclin D1, melanoma, skin carcinogenesis

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