RT Journal Article
T1 An update on the implications of cyclin D1 in melanomas.
A1 González-Ruiz, Lucia
A1 González-Moles, Miguel Ángel
A1 González-Ruiz, Isabel
A1 Ruiz-Ávila, Isabel
A1 Ayén, Ángela
A1 Ramos-García, Pablo
K1 CCND1
K1 cyclin D1
K1 melanoma
K1 skin carcinogenesis
AB Cyclin D1 is a protein encoded by the CCND1 gene, located on 11q13 chromosome, which is a key component of the physiological regulation of the cell cycle. CCND1/cyclin D1 is upregulated in several types of human tumors including melanoma and is currently classified as an oncogene that promotes uncontrolled cell proliferation. Despite the demonstrated importance of CCND1/cyclin D1 as a central oncogene in several types of human tumors, its knowledge in melanoma is still limited. This review examines data published on upregulation of the CCND1 gene and cyclin D1 protein in the melanoma setting, focusing on the pathways and molecular mechanisms involved in the activation of the gene and on the clinical and therapeutic implications.
YR 2020
FD 2020-03-20
LK http://hdl.handle.net/10668/15215
UL http://hdl.handle.net/10668/15215
LA en
DS RISalud
RD Apr 7, 2025