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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test.

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Date

2020-09-29

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Garces, Maria Fernanda
Buell-Acosta, Julieth Daniela
Rodriguez-Navarro, Haiver Antonio
Pulido-Sanchez, Estefania
Rincon-Ramirez, Juan Jose
Moreno-Ordoñez, Diana Carolina
Franco-Vega, Roberto
Roncancio-Muñoz, Jhoan Sebastian
Burgos-Cardenas, Alvaro Javier
Lacunza, Ezequiel

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Nature Publishing Group
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This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m2) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m2) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p 

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MeSH Terms

Angiopoietin-Like Protein 3
Angiopoietin-like Proteins
Blood Glucose
Diabetes Mellitus
Fasting
Glucose Tolerance Test
Humans
Insulin
Insulin Resistance
Male
Obesity
Young Adult

DeCS Terms

Diabetes mellitus
Glucemia
Proteina 3 similar a la angiopoyetina
Prueba de tolerancia a la glucosa
Resistencia a la insulina
Ayuno
Insulina
Obesidad

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Garcés MF, Buell-Acosta JD, Rodríguez-Navarro HA, Pulido-Sánchez E, Rincon-Ramírez JJ, Moreno-Ordóñez DC, et al. Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test. Sci Rep. 2020 Dec 3;10(1):21118