Palau-Rodriguez, MagaliTulipani, SaraMarco-Ramell, AnnaMiñarro, AntonioJauregui, OlgaGonzalez-Dominguez, RaulSanchez-Pla, AlexRamos-Molina, BrunoTinahones, Francisco JAndres-Lacueva, Cristina2023-01-252023-01-252018-06-29http://hdl.handle.net/10668/12578The exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses, was carried out to distinguish those metabolites associated with metabolic improvement. Hydroxypropionic acids, medium-/long-chain hydroxy fatty acids, and bile acid glucuronides were the most discriminative biomarkers of response between MH and MU phenotypes. Hydroxypropionic (hydroxyphenyllactic-related) acids, amino acids, and glycerolipids were the most significant clusters of metabolites altered after bariatric surgery in MU ( penCC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/bariatric surgeryhydroxyphenyllacticindole metabolitesmass spectrometrymetabolically healthymicrobiota metabotypeobesityuntargeted metabolomicsAdultAmino AcidsBariatric SurgeryBiomarkersFatty AcidsFemaleHumansLactatesLipid MetabolismMaleMetabolomicsMiddle AgedObesity, MorbidPropionatesresearch article29893570open access10.1021/acs.jproteome.8b001441535-3907http://diposit.ub.edu/dspace/bitstream/2445/162377/1/683368.pdf