Troulé, KevinLópez-Fernández, HugoGarcía-Martín, SantiagoReboiro-Jato, MiguelCarretero-Puche, CarlosMartorell-Marugán, JordiMartín-Serrano, GuillermoCarmona-Sáez, PedroGlez-Peña, DanielAl-Shahrour, FátimaGómez-López, Gonzalo2023-02-092023-02-092021http://hdl.handle.net/10668/16121Drug immunomodulation modifies the response of the immune system and can be therapeutically exploited in pathologies such as cancer and autoimmune diseases. DREIMT is a new hypothesis-generation web tool, which performs drug prioritization analysis for immunomodulation. DREIMT provides significant immunomodulatory drugs targeting up to 70 immune cells subtypes through a curated database that integrates 4960 drug profiles and ∼2600 immune gene expression signatures. The tool also suggests potential immunomodulatory drugs targeting user-supplied gene expression signatures. Final output includes drug-signature association scores, FDRs and downloadable plots and results tables. http://www.dreimt.org. Supplementary data are available at Bioinformatics online.enDatabases, FactualDatabases, PharmaceuticalDrug RepositioningImmunomodulationTranscriptomeresearch article32818254open access10.1093/bioinformatics/btaa7271367-4811https://academic.oup.com/bioinformatics/article-pdf/37/4/578/37757681/btaa727.pdf