Ramos-Rincon, Jose-ManuelLópez-Carmona, María-DoloresCobos-Palacios, LidiaLópez-Sampalo, AlmudenaRubio-Rivas, ManuelMartín-Escalante, María-Doloresde-Cossio-Tejido, SantiagoTaboada-Martínez, María-LuisaMuiño-Miguez, AntonioAreses-Manrique, MariaMartinez-Cilleros, CarmenTuñón-de-Almeida, CarlotaAbella-Vázquez, LucyMartínez-Gonzalez, Angel-LuísDíez-García, Luis-FelipeRipper, Carlos-JorgeAsensi, VictorMartinez-Pascual, AngelesGuisado-Vasco, PabloLumbreras-Bermejo, CarlosGómez-Huelgas, RicardoOn Behalf Of The Semi-Covid-Network,2023-05-032023-05-032022-06-292077-0383http://hdl.handle.net/10668/21309(1) Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients ≥ 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were ≥80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29−0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22−0.61) (penAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2Spainage ≥ 80mortalityremdesivirresearch article35807058open access10.3390/jcm11133769PMC9267524https://www.mdpi.com/2077-0383/11/13/3769/pdf?version=1656566977https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9267524/pdf