Paredes, IgorCastaño Leon, Ana MariaLagares, AlfonsoJimenez Roldan, LuisPerez-Nuñez, AngelGonzález-Leon, PedroDelgado-Fernandez, JuanEiriz, CarlaGarcía-Pérez, DanielMoreno-Gomez, Luis MiguelEsteban-Sinovas, OlgaDelgado-López, PedroMartín-Alonso, JavierKaen, ArielTirado-Caballero, JorgeOrdóñez Carmona, MartaArteaga Romero, FranciscoGonzalez Pombo, MartaAlén, José FGil-Simoes, RicardoTorres, Cristina VNavas Garcia, MartaBlasco, GuillermoFrade-Porto, NataliaGonzález-Tarno, PatriciaMartin Segura, AdrianGelabert-Gonzalez, MiguelMenendez Cortezon, BeatrizRodriguez Botana, BraisPérez-Alfayate, RebecaFernandez Garcia, CarlaFerrandez Pujante, BorjaVargas-Jiménez, AndresCotúa, Carlosde la Lama, AdolfoCalero, LourdesRuiz-Juretschke, FernandoGarcia Leal, RobertoValera Mele, MarcCasitas Hernando, VicenteRivero Martín, BelénOrduna, JavierCasado Pellejero, JuanFustero De Miguel, DavidDiaz-Molina, JorgeMoles Herbera, JesusCastello Ruiz, Maria JoseGomar Alba, MarioGarcia Perez, FernandoHernandez Garcia, Borja JesusVillaseñor Ledezma, JavierOtero Rodríguez, ÁlvaroAilagas, Juan JoséGoncalves-Estella, JesúsSousa Casasnovas, PabloPascual Argente, DanielRuiz Martín, LauraRoa Montes de Oca, Juan CarlosArandia Guzmán, DanielGarcía Martín, AndoniTorres Carretero, LuisGarrido Ruíz, Patricia AlejandraCalvo, MartaMiranda-Lloret, PabloRodriguez-Cadarso Suarez-Vence, MiguelAnotn Oltra, JoanRoca Barber, AmparoQuiroz Tejada, ArnoldCarbayo Lozano, GuillermoBermudez Vilar, GaraziPaternain Martin, ClaraDela FuenteVilla, PabloFidalgo De la Rosa, MarinaSistiaga García, Íñigo LZabalo San Juan, Gorka2025-01-072025-01-072021-12-10https://hdl.handle.net/10668/24916To assess the effect of the first wave of the SARS-CoV-2 pandemic on the outcome of neurosurgical patients in Spain. The initial flood of COVID-19 patients overwhelmed an unprepared healthcare system. Different measures were taken to deal with this overburden. The effect of these measures on neurosurgical patients, as well as the effect of COVID-19 itself, has not been thoroughly studied. This was a multicentre, nationwide, observational retrospective study of patients who underwent any neurosurgical operation from March to July 2020. An exploratory factorial analysis was performed to select the most relevant variables of the sample. Univariate and multivariate analyses were performed to identify independent predictors of mortality and postoperative SARS-CoV-2 infection. Sixteen hospitals registered 1677 operated patients. The overall mortality was 6.4%, and 2.9% (44 patients) suffered a perioperative SARS-CoV-2 infection. Of those infections, 24 were diagnosed postoperatively. Age (OR 1.05), perioperative SARS-CoV-2 infection (OR 4.7), community COVID-19 incidence (cases/105 people/week) (OR 1.006), postoperative neurological worsening (OR 5.9), postoperative need for airway support (OR 5.38), ASA grade ≥3 (OR 2.5) and preoperative GCS 3-8 (OR 2.82) were independently associated with mortality. For SARS-CoV-2 postoperative infection, screening swab test Perioperative SARS-CoV-2 infection in neurosurgical patients was associated with an increase in mortality by almost fivefold. Community COVID-19 incidence (cases/105 people/week) was a statistically independent predictor of mortality. CEIM 20/217.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/adult surgeryneurological injuryneurological oncologyneurosurgeryCOVID-19HumansPandemicsRetrospective StudiesSARS-CoV-2Spainresearch article34893486open access10.1136/bmjopen-2021-0539832044-6055PMC9065769https://bmjopen.bmj.com/content/bmjopen/11/12/e053983.full.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC9065769/pdf