Aparicio, Virginia ABaena-García, LauraFlor-Alemany, MartaMartínez-González, Luis JVarela-López, AlfonsoSánchez, CristinaQuiles, José L2023-05-032023-05-032022http://hdl.handle.net/10668/20227To explore the differences in some maternal-neonatal metabolic markers and placenta status by foetal sex. One hundred thirty-nine Caucasian pregnant women from the GESTAFIT project and their new-borns were included in the present cross-sectional study. Serum cardiometabolic markers (i.e. lipid and glycaemic profile and uric acid) were analysed at late pregnancy and at birth. In placenta, telomeres length, proportion of deleted mitochondrial-DNA and mitochondrial-DNA density, some minerals and interleukin 8, epidermal growth factor, fibroblast growth factor-2 and vascular endothelial growth factor were measured. The study was run between November 2015 and April 2018. Mothers carrying a male showed higher serum triglycerides than mothers carrying a female at late pregnancy (p  Our findings show weak differences in some cardiometabolic and placental status markers by foetal sex. Notwithstanding, we observed a slightly more proatherogenic profile in both, mothers carrying males' foetuses and male new-borns. We also found lower serum uric acid and better placenta status in mothers carrying a female. These findings indicate that foetal sex might need to be considered for a more personalized follow-up of pregnancies.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/fibroblast Growth FactorlipidsnewbornpregnancytelomeretriglyceridesBiomarkersCardiovascular DiseasesCross-Sectional StudiesDNAFemaleFibroblast Growth Factor 2HumansInfant, NewbornMalePlacentaPregnancySex FactorsUric AcidVascular Endothelial Growth Factor Aresearch article35989614open access10.1177/174550572211179761745-5065PMC9393354https://doi.org/10.1177/17455057221117976https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393354/pdf