Kowalski, Marek LAgache, IoanaBavbek, SevimBakirtas, ArzuBlanca, MiguelBochenek, GrazynaBonini, MatteoHeffler, EnricoKlimek, LudgerLaidlaw, Tanya MMullol, JoaquimNizankowska-Mogilnicka, EwaPark, Hae-SimSanak, MarekSanchez-Borges, MarioSanchez-Garcia, SilviaScadding, GlenisTaniguchi, MasamiTorres, Maria JWhite, Andrew AWardzynska, Aleksandra2023-01-252023-01-252019-01-30Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, et al. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019 Jan;74(1):28-39http://hdl.handle.net/10668/12946NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the respiratory tract occurring in patients with asthma and/or chronic rhinosinusitis with nasal polyps (CRSwNP), symptoms of which are exacerbated by NSAIDs, including aspirin. Despite some progress in understanding of the pathophysiology of the syndrome, which affects 1/10 of patients with asthma and rhinosinusitis, it remains a diagnostic and therapeutic challenge. In order to provide evidence-based recommendations for the diagnosis and management of N-ERD, a panel of international experts was called by the EAACI Asthma Section. The document summarizes current knowledge on the pathophysiology and clinical presentation of N-ERD pointing at significant heterogeneity of this syndrome. Critically evaluating the usefulness of diagnostic tools available, the paper offers practical algorithm for the diagnosis of N-ERD. Recommendations for the most effective management of a patient with N-ERD stressing the potential high morbidity and severity of the underlying asthma and rhinosinusitis are discussed and proposed. Newly described sub-phenotypes and emerging sub-endotypes of N-ERD are potentially relevant for new and more specific (eg, biological) treatment modalities. Finally, the document defines major gaps in our knowledge on N-ERD and unmet needs, which should be addressed in the future.enAERDENT (rhinitis, sinusitis, nasal polyps…)AsthmaAsthma treatmentDrug allergySinusitisAlgorithmsAnti-Inflammatory Agents, Non-SteroidalAsthmaAsthma, Aspirin-InducedDisease ManagementHumansRespiratory Tract DiseasesRhinitisSinusitisresearch article30216468Restricted AccessAsmaAntiinflamatorios no EsteroideosPredicciónNecesidades y Demandas de Servicios de SaludAspirinaPólipos NasalesSistema Respiratorio10.1111/all.135991398-9995https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.13599