Blanco, APuiggros, ABaliakas, PAthanasiadou, AGarcía-Malo, MDCollado, RXochelli, ARodríguez-Rivera, MOrtega, MCalasanz, MJLuño, EVargas, MTGrau, JMartínez-Laperche, CValiente, APapaioannou, GCervera, JAnagnostopoulos, APiñán, MAStalika, EHernández-Rivas, JMBatlle, ASalido, MOrtuño, FMelero, cRobles, DFerrer, AIvars, DRodríguez, AGonzález, MBosch, FAbrisqueta, PStamatopoulos, KEspinet, B2016-11-232016-11-232016-06-09Blanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo MD, Collado R, el al. Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A. HAEMATOLOGICA. 2016, Vol. 101, (S1) pp. 229-2300390-6078http://hdl.handle.net/10668/2539TP53 aberrations (deletions and/or mutations, TP53ab) in chronic lymphocytic leukemia (CLL) are associated with dismal clinical outcome and reduced life expectancy. However, mounting evidence suggests that within cases carrying TP53ab other cytogenetic features may also influence the clinical outcome. Alterations in chromosome 8, in particular 8p losses (affecting several regions, from 8p12 to 8p23) and 8q gains (usually involving 8q24, where MYC is located), are enriched in TP53ab patients and have been proposed as features with potential prognostic value within this aggressive group.enCromosomas humanos par 8CitogenéticaLeucemia linfoideEsperanza de vidaEliminación de secuenciaMedical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 6-12 and X::Chromosomes, Human, Pair 8Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::CytogeneticsMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, LymphoidMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Life ExpectancyMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::MutationMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::PrevalenceMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Mutagenesis::Sequence Deletionconference presentationopen access1592-8721