Rodriguez-Baño, JesusGutierrez-Gutierrez, BelenPascual, Alvaro2022-10-272022-10-272021-02-24Rodríguez-Baño J, Gutiérrez-Gutiérrez B, Pascual A. CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales. JAC Antimicrob Resist. 2021 Feb 24;3(1):dlaa112http://hdl.handle.net/10668/4290Carbapenems are considered the drugs of choice for the treatment of serious infections caused by ceftriaxone-resistant Enterobacterales. However, because of the dramatic increase in carbapenem-resistant organisms worldwide, finding alternatives to carbapenems is a must. The potential options include β-lactam/β-lactamase inhibitor combinations, temocillin, cephamycins and some non-β-lactam drugs. The most controversial is piperacillin/tazobactam; the results of the MERINO trial are challenged because the isolates of patients with worse outcomes were frequently not susceptible to piperacillin/tazobactam when studied by reference methods, and also because the drug was not administered in extended infusion. Other potential options are briefly discussed. We conclude that carbapenems are not necessary for all patients with infections caused by ceftriaxone-resistant Enterobacterales.enAtribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/CeftriaxoneCarbapenemsCephamycinsLactamsInfectionsPiperacillin/tazobactamPneumoniaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::Cephacetrile::Cefotaxime::CeftriaxoneMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::CarbapenemsMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins::CephamycinsMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection::Pneumonia, Ventilator-AssociatedMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Sepsis::Shock, SepticMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial AgentsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::AminoglycosidesMedical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Meningitisresearch article34223064open accessCeftriaxonaCarbapenémicosCefamicinasLactamasCombinación piperacilina y tazobactamNeumonía10.1093/jacamr/dlaa1122632-1823PMC8210108