Perez, Tamara AlonsoCastillo, Elena GarcíaAncochea, JulioPastor Sanz, María TeresaAlmagro, PereMartínez-Camblor, PabloMiravitlles, MarcRodríguez-Carballeira, MónicaNavarro, AnnieLamprecht, BerndRamírez-García Luna, Ana SKaiser, BernhardAlfageme, InmaculadaCasanova, CiroEsteban, CristóbalSoler-Cataluña, Juan JDe-Torres, Juan PCelli, Bartolomé RMarin, Jose MLopez-Campos, Jose LRiet, Gerben TerSobradillo, PatriciaLange, PeterGarcia-Aymerich, JudithAnto, Josep MTurner, Alice MHan, MeiLan KLanghammer, ArnulfSternberg, AliceLeivseth, LindaBakke, PerJohannessen, AneOga, ToruCosío, BorjaEchazarreta, AndresRoche, NicolasBurgel, Pierre-RégisSin, Don DPuhan, Milo ASoriano, Joan B2023-02-092023-02-092020-08-13http://hdl.handle.net/10668/16170There is partial evidence that COPD is expressed differently in women than in men, namely on symptoms, pulmonary function, exacerbations, comorbidities or prognosis. There is a need to improve the characterization of COPD in females. We obtained and pooled data of 17 139 patients from 22 COPD cohorts and analysed the clinical differences by sex, establishing the relationship between these characteristics in women and the prognosis and severity of the disease. Comparisons were established with standard statistics and survival analysis, including crude and multivariate Cox-regression analysis. Overall, 5355 (31.2%) women were compared with men with COPD. Women were younger, had lower pack-years, greater FEV1%, lower BMI and a greater number of exacerbations (all p  COPD in women has some characteristic traits expressed differently than compared to men, mainly with more dyspnea and COPD exacerbations and less phlegm, among others, although long-term survival appears better in female COPD patients.enCOPDFemaleSexSurvivalAge FactorsBody Mass IndexComorbidityDisease ProgressionDyspneaFemaleForced Expiratory VolumeHumansMalePrognosisProspective StudiesPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSex CharacteristicsSputumSurvival RateTime Factorsresearch article32858497open access10.1016/j.rmed.2020.1061051532-3064http://www.resmedjournal.com/article/S0954611120302456/pdf