Blanco-Reina, EncarnaciónAguilar-Cano, LorenaGarcía-Merino, María RosaOcaña-Riola, RicardoValdellós, JeniferBellido-Estévez, InmaculadaAriza-Zafra, Gabriel2022-09-212022-09-212021-08-14Blanco-Reina E, Aguilar-Cano L, García-Merino MR, Ocaña-Riola R, Valdellós J, Bellido-Estévez I, et al. Assessing Prevalence and Factors Related to Frailty in Community-Dwelling Older Adults: A Multinomial Logistic Analysis. J Clin Med. 2021 Aug 14;10(16):3576http://hdl.handle.net/10668/4084Frailty is an age-related clinical condition that typically involves a deterioration in the physiological capacity of various organ systems and heightens the patient's susceptibility to stressors. For this reason, one of the main research goals currently being addressed is that of characterising the impact of frailty in different settings. The main aim of this study is to determine the prevalence of Fried's frailty phenotype among community-dwelling older people and to analyse the factors associated with frailty. In this research study, 582 persons aged 65 years or more participated in this cross-sectional study that was conducted at primary healthcare centres in Málaga, Spain. Sociodemographic, clinical, functional and comprehensive drug therapy data were compiled. The relationship between the independent variables and the different states of frailty was analysed by using a multinomial logistic regression model. Frailty was present in 24.1% of the study sample (95% CI = 20.7-27.6) of whom 54.3% were found to be pre-frail and 21.6% were non-frail. The study variable most strongly associated with frailty was the female gender (OR = 20.54, 95% CI = 9.10-46.3). Other factors found to be associated with the state of frailty included age, dependence for the instrumental activities of daily living (IADL), polymedication, osteoarticular pathology and psychopathology. This study confirms the high prevalence of frailty among community-dwelling older people. Frailty may be associated with many factors. Some of these associated factors may be preventable or modifiable and, thus, provide clinically relevant targets for intervention. This is particularly the case for depressive symptoms, the clinical control of osteoarthritis and the use of polypharmacy.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/FrailtyOlder adultsPolymedicationOsteoarticular pathologyPsychopathologyPrimary careFragilidadPersonas mayores frágilesPolimedicaciónArtropatíasPsicopatologíaAtención primaria de saludMedical Subject Headings::Persons::Persons::Age Groups::Adult::AgedMedical Subject Headings::Persons::Persons::Age Groups::Adult::Aged::Frail ElderlyMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Activities of Daily LivingMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Activities of Daily Living::Independent LivingMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional StudiesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::PolypharmacyMedical Subject Headings::Information Science::Information Science::Data Collection::Vital Statistics::Morbidity::PrevalenceMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::DepressionMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::SpainMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::PhenotypeMedical Subject Headings::Health Care::Health Services Administration::Patient Care Management::Comprehensive Health Care::Primary Health CareMedical Subject Headings::Psychiatry and Psychology::Mental DisordersMedical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Osteoarthritisresearch article34441873open access10.3390/jcm101635762077-0383PMC8397006