Fortner, Renée TPoole, Elizabeth MWentzensen, Nicolas ATrabert, BrittonWhite, EmilyArslan, Alan APatel, Alpa VSetiawan, V WendyVisvanathan, KalaWeiderpass, ElisabeteAdami, Hans-OlovBlack, AmandaBernstein, LeslieBrinton, Louise ABuring, JulieClendenen, Tess VFournier, AgnèsFraser, GaryGapstur, Susan MGaudet, Mia MGiles, Graham GGram, Inger THartge, PatriciaHoffman-Bolton, JudithIdahl, AnnikaKaaks, RudolfKirsh, Victoria AKnutsen, SynnoveKoh, Woon-PuayLacey, James VLee, I-MinLundin, EvaMerritt, Melissa AMilne, Roger LOnland-Moret, N CharlottePeters, UlrikePoynter, Jenny NRinaldi, SabinaRobien, KimRohan, ThomasSanchez-Perez, Maria-JoseSchairer, CatherineSchouten, Leo JTjonneland, AnneTownsend, Mary KTravis, Ruth CTrichopoulou, Antoniavan den Brandt, Piet AVineis, PaoloWilkens, LynneWolk, AlicjaYang, Hannah PZeleniuch-Jacquotte, AnneTworoger, Shelley S2023-01-252023-01-252019-01-14http://hdl.handle.net/10668/13324Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial variability in outcomes. We hypothesized that risk factor profiles may influence tumor aggressiveness, defined by time between diagnosis and death, independent of histology. Among 1.3 million women from 21 prospective cohorts, 4,584 invasive epithelial ovarian cancers were identified and classified as highly aggressive (death inenaggressivenessovarian cancerprospective cohortrisk factorssubtypesAgedBody Mass IndexCarcinoma, Ovarian EpithelialCohort StudiesFemaleHumansMiddle AgedNeoplasm InvasivenessOvarian NeoplasmsParityPregnancyProportional Hazards ModelsProspective StudiesRisk FactorsSmokingresearch article30561796open access10.1002/ijc.320751097-0215PMC6488363https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.32075https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488363/pdf