Sartelli, MassimoCatena, FaustoAnsaloni, LucaLeppaniemi, AriTaviloglu, Korhanvan Goor, HarryViale, PierluigiLazzareschi, Daniel VascoCoccolini, FedericoCorbella, Davidede Werra, CarloMarrelli, DanieleColizza, SergioScibè, RodolfoAlis, HalilTorer, NurkanNavarro, SalvadorSakakushev, BorisMassalou, DamienAugustin, GoranCatani, MarcoKauhanen, SailaPletinckx, PieterKenig, JakubDi Saverio, SalomoneJovine, ElioGuercioni, GianlucaSkrovina, MatejDíaz-Nieto, RafaelFerrero, AlessandroRausei, StefanoLaine, SamipetteriMajor, PiotrAngst, ElianePittet, OlivierHerych, IhorAgresta, FerdinandoVettoretto, NereoPoiasina, EliaTepp, JaanWeiss, GunterVasquez, GiorgioVladov, NikolaTranà, CristianDelibegovic, SamirDziki, AdamGiraudo, GiorgioPereira, JorgeTzerbinis, Helenvan Dellen, DavidHutan, MartinVereczkei, AndrasKrasniqi, AvdylSeretis, CharalamposMesina, CristianRems, MiranCampanile, Fabio CesareColetta, PietroUotila-Nieminen, MirjamiDente, MarioBouliaris, KonstantinosLasithiotakis, KonstantinosKhokha, VladimirZivanovic, DragoljubSmirnov, DmitryMarinis, AthanasiosNegoi, IonutNey, LudwigBini, RobertoLeón, MiguelAloia, SergioHuchon, CyrilleMoldovanu, Radude Melo, Renato BessaGiakoustidis, DimitriosIoannidis, OrestisCucchi, MichelePintar, TadejaKrivokapic, ZoranPetrovic, Jelena2013-06-102013-06-102012-11-29Sartelli M, Catena F, Ansaloni L, Leppaniemi A, Taviloglu K, van Goor H, et al. Complicated intra-abdominal infections in Europe: a comprehensive review of the CIAO study. World J Emerg Surg. 2012; 7(1):36http://hdl.handle.net/10668/1112Journal Article;The CIAO Study ("Complicated Intra-Abdominal infection Observational" Study) is a multicenter investigation performed in 68 medical institutions throughout Europe over the course of a 6-month observational period (January-June 2012).Patients with either community-acquired or healthcare-associated complicated intra-abdominal infections (IAIs) were included in the study.2,152 patients with a mean age of 53.8 years (range: 4-98 years) were enrolled in the study. 46.3% of the patients were women and 53.7% were men. Intraperitoneal specimens were collected from 62.2% of the enrolled patients, and from these samples, a variety of microorganisms were collectively identified.The overall mortality rate was 7.5% (163/2.152).According to multivariate analysis of the compiled data, several criteria were found to be independent variables predictive of patient mortality, including patient age, the presence of an intestinal non-appendicular source of infection (colonic non-diverticular perforation, complicated diverticulitis, small bowel perforation), a delayed initial intervention (a delay exceeding 24 hours), sepsis and septic shock in the immediate post-operative period, and ICU admission.Given the sweeping geographical distribution of the participating medical centers, the CIAO Study gives an accurate description of the epidemiological, clinical, microbiological, and treatment profiles of complicated intra-abdominal infections (IAIs) throughout Europe.enInfecciones IntraabdominalesEstudio MulticéntricoAbceso AbdominalEnfermedad CríticaHumanosProcedimientos Quirúrgicos del Sistema DigestivoFarmacoresistencia MicrobianaReoperaciónInfección HospitalariaAdultoMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Intraabdominal InfectionsMedical Subject Headings::Publication Characteristics::Study Characteristics::Multicenter StudyMedical Subject Headings::Diseases::Digestive System Diseases::Peritoneal Diseases::PeritonitisMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Suppuration::Abscess::Abdominal AbscessMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Critical IllnessMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::DrainageMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Digestive System Surgical ProceduresMedical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Drug Resistance, MicrobialMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::SepsisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::ReoperationMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross InfectionMedical Subject Headings::Named Groups::Persons::Age Groups::Adultresearch article23190741open access10.1186/1749-7922-7-361749-7922PMC3539964