Lafont, AlexandreSinnaeve, Peter RCuisset, ThomasCook, StéphaneSideris, GiorgiosKedev, SaskoCarrie, DidierHovasse, ThomasGarot, PhilippeEl Mahmoud, RamiSpaulding, ChristianHelft, GérardDiaz Fernandez, José FBrugaletta, SalvatorePinar-Bermudez, EduardoFerre, Josepa MauriCommeau, PhilippeTeiger, EmmanuelBogaerts, KrisSabate, ManelMorice, Marie ClaudeVarenne, OlivierSENIOR investigators2023-02-092023-02-092020-08-06http://hdl.handle.net/10668/16060Report the results at 2 years of the patients included in the SENIOR trial. Patients above 75 years of age represent a fast-growing population in the cathlab. In the SENIOR trial, patients treated by percutaneous coronary intervention (PCI) with drug eluting stent (DES) and a short duration of P2Y12 inhibitor (1 and 6 months for stable and unstable coronary syndromes, respectively) compared with bare metal stents (BMS) was associated with a 29% reduction in the rate of all-cause mortality, myocardial infarction (MI), stroke, and ischaemia-driven target lesion revascularization (ID-TLR) at 1 year. The results at 2 years are reported here. We randomly assigned 1,200 patients (596[50%] to the DES group and 604[50%] to the BMS group). At 2 years, the composite endpoint of all-cause mortality, MI, stroke and ID-TLR had occurred in 116 (20%) patients in the DES group and 131 (22%) patients in the BMS group (RR 0.90 [95%CI 0.72-1.13], p = .37). IDTLR occurred in 14 (2%) patients in the DES group and 41 (7%) patients in the BMS group (RR 0.35 [95%CI 0.16-0.60], p = .0002). Major bleedings (BARC 3-5) occurred in 27(5%) patients in both groups (RR 1.00, [95%CI 0.58-1.75], p = .99). Stent thrombosis rates were low and similar between DES and BMS (0.8 vs 1.3%, (RR 0.52 [95%CI 0.01-1.95], p = .27). Among elderly PCI patients, a strategy combining a DES together with a short duration of DAPT is associated with a reduction in revascularization up to 2 years compared with BMS with very few late events and without any increased in bleeding complications or stent thrombosis.enPCIbare metal stentsdrug eluting stentselderly patientsshort DAPTAgedCoronary Artery DiseaseDrug-Eluting StentsHumansPercutaneous Coronary InterventionProsthesis DesignRisk FactorsStentsTreatment Outcomeresearch article32761890open access10.1002/ccd.291591522-726Xhttps://lirias.kuleuven.be/bitstream/123456789/669028/2/SENIOR%202%20Years%20Final%20revised05062020.pdf