Zavala-Crichton, Juan PabloEsteban-Cornejo, IreneSolis-Urra, PatricioMora-Gonzalez, JoséCadenas-Sanchez, CristinaRodriguez-Ayllon, MaríaMigueles, Jairo H.Molina-Garcia, PabloVerdejo-Roman, JuanKramer, Arthur F.Hillman, Charles H.Erickson, Kirk I.Catena, AndrésOrtega, Francisco B.2022-09-232022-09-232020-04-12Zavala-Crichton JP, Esteban-Cornejo I, Solis-Urra P, Mora-Gonzalez J, Cadenas-Sanchez C, Rodriguez-Ayllon M, et al. Association of Sedentary Behavior with Brain Structure and Intelligence in Children with Overweight or Obesity: The ActiveBrains Project. J Clin Med. 2020 Apr 12;9(4):1101http://hdl.handle.net/10668/4124We investigated the associations of di_erent sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter volume in six brain regions (_ ranging 􀀀0.314 to 􀀀0.489 and cluster size 106 to 323 voxels; p < 0.001), playing video games in three brain regions (_ ranging 􀀀0.391 to 􀀀0.359, and cluster size 96 to 461 voxels; p < 0.001) and total sedentary time in two brain regions (_ ranging 􀀀0.341 to 􀀀0.352, and cluster size 897 to 2455 voxels; p < 0.001). No brain regions showed a significant positive association (all p > 0.05). Two brain regions were related, or borderline related, to intelligence. Conclusions: SB could have the potential to negatively influence brain structure and, in turn, intelligence in children with overweight/obesity.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/SedentarinessTV viewingMagnetic resonance imagingBrainCognitionChildhoodObesitySedentary behaviorImagen por resonancia magnéticaEncéfaloCogniciónObesidadConducta sedentariaMedical Subject Headings::Persons::Persons::Age Groups::AdolescentMedical Subject Headings::Persons::Persons::Age Groups::ChildMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::BrainMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional StudiesMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::OverweightMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::SpainMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Personality::IntelligenceMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::ObesityMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Nutrition Assessment::Nutrition Surveys::Diet SurveysMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::QuestionnairesMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Human Activities::Leisure Activities::Recreation::Play and Playthings::Video GamesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humansresearch article32290576open access10.3390/jcm90411012077-0383PMC7230478