Lemus-Conejo, AnaGrao-Cruces, ElenaToscano, RocioVarela, Lourdes MClaro, CarmenPedroche, JustoMillan, FranciscoMillan-Linares, Maria CMontserrat-de la Paz, Sergio2023-02-082023-02-082020-04-08Lemus-Conejo A, Grao-Cruces E, Toscano R, Varela LM, Claro C, Pedroche J, et al. A lupine (Lupinus angustifolious L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice. Food Funct. 2020 Apr 30;11(4):2943-2952.http://hdl.handle.net/10668/15343Bioactive peptides are related to the prevention and treatment of many diseases. GPETAFLR is an octapeptide that has been isolated from lupine (Lupinus angustifolius L.) and shows anti-inflammatory properties. The aim of this study was to evaluate the potential activity of GPETAFLR to prevent non-alcoholic fatty liver disease (NAFLD) in high-fat-diet (HFD)-induced obese mice. C57BL/6J mice were fed a standard diet or HFD. Two of the groups fed the HFD diet were treated with GPETAFLR in drinking water at 0.5 mg kg-1 day-1 or 1 mg kg-1 day-1. To determine the ability of GPETAFLR to improve the onset and progression of non-alcoholic fatty liver disease, histological studies, hepatic enzyme profiles, inflammatory cytokine and lipid metabolism-related genes and proteins were analysed. Our results suggested that HFD-induced inflammatory metabolic disorders were alleviated by treatment with GPETAFLR. In conclusion, dietary lupine consumption can repair HFD-induced hepatic damage possibly via modifications of liver's lipid signalling pathways.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/AnimalsDiet, High-FatFunctional FoodMice, Inbred C57BLPlant ExtractsRandom AllocationAdministration, OralAnti-Inflammatory AgentsDisease Models, AnimalLupinusMaleMiceNon-alcoholic Fatty Liver DiseaseObesityresearch article32267269open accessLupinusProteínasPéptidosHígadoEnzimasCitocinasRatones obesos10.1039/d0fo00206b2042-650Xhttps://pubs.rsc.org/en/content/articlepdf/2020/fo/d0fo00206b