Campos-Arjona, RafaelRodríguez-Capitán, JorgeMartínez-Carmona, José DLavreshin, AlexeyFernández-Romero, LoudesMelero-Tejedor, José MJiménez-Navarro, Manuel2023-05-032023-05-032022-07-15http://hdl.handle.net/10668/21666Our aim was to evaluate the development of new significant mitral regurgitation and long-term survival after mitral repair surgery in functional mitral regurgitation. A retrospective observational analysis of the recurrence of functional mitral regurgitation (ischemic and nonischemic) and global mortality during follow-up of 176 patients who underwent mitral repair surgery between 1999 and 2018 in our center was conducted. The etiology of functional mitral regurgitation was ischemic in 55.7% of cases. After surgery, mitral regurgitation was 0-I in 92.3% of cases. We conducted a long-term clinical follow-up of a mean 42.2 months and an echocardiographic follow-up of a mean 41.8 months. We observed mitral regurgitation of at least grade II in 52 patients (36.9%). Survival at 1, 3, and 5 years was 78.8%, 66.7%, and 52.3%, respectively. Predictive factors for global mortality were age (hazard ratio = 1.038, p = 0.01) and a depressed preoperative ejection fraction. After a competing risk analysis, we found the only predictive factor for the recurrence of mitral regurgitation in our series to be age (sub-hazard ratio = 1.03, 95% confidence interval = 1.01-1.06, p = 0.016). Repair surgery for functional mitral regurgitation shows age as the only independent predictor of recurrence. Age and depressed ejection fraction were predictors of mortality.enAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/functional mitral regurgitationmitral regurgitationmitral valve repairmitral valve surgeryrecurrent mitral regurgitationHumansMitral Valve InsufficiencyMitral ValveRetrospective StudiesTreatment OutcomePrognosisresearch article35851568open access10.5761/atcs.oa.22-000512186-1005PMC9585337https://www.jstage.jst.go.jp/article/atcs/advpub/0/advpub_oa.22-00051/_pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585337/pdf