Cánovas, Manuel SánchezGaray, David FernándezMoran, Laura OrtegaPérez, Jaime RubioRubio, Carlos Miguel Guiraode Mena, Miriam LoboPortero, Berta ObispoCastro, Jesús BrenesLage, YolandaLavin, Diego CachoBlanco, Ana Belen Rupérezde Soignie, Ana Manuela Martín FernándezPerejón, Jonatan Zacarías BenoitColomo, Laura JiménezBoluda, Noel BlayaMoreno, Javier BosqueVerduguez, Teresa QuintanarGarrido, Carmen RosaHuertas, Roberto MartínPuig, Carme Font IMartín, Andrés Jesús Muñoz2023-05-032023-05-032022-06-06http://hdl.handle.net/10668/21175Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice. Retrospective, multicenter study promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM). Patients with melanoma and lung cancer who initiated ICI between 01/01/2015 and 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it was not possible because of death). The primary objective was to calculate the incidence of ICI-associated VTE/AT and the secondary objectives included to analyze its impact on survival and to identify predictor variables for VTE/AT. 665 patients with lung cancer were enrolled. The incidence of VTE/AT during follow-up was 8.4%. Median overall survival (OS) was lower in the VTE/AT group (12 months 95% CI 4.84-19.16 vs. 19 months 95% CI 16.11-21.9; p = 0.0049). Neutrophil/lymphocyte ratio (NLR) and anemia upon initiation of IT, as well as a history of thrombosis between cancer diagnosis and the start of ICI, were predictive variables for developing of VTE/AT (p  ICI increases the risk of VTE/AT in patients with lung cancer and melanoma, which impact OS.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Cancer related thrombosisImmune Checkpoint InhibitorsLung cancerMelanomaHumansImmune Checkpoint InhibitorsLung NeoplasmsMedical OncologyMelanomaPrognosisRetrospective StudiesThrombosisVenous Thromboembolismresearch article35668339open access10.1007/s12094-022-02860-51699-3055PMC9418291https://link.springer.com/content/pdf/10.1007/s12094-022-02860-5.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9418291/pdf