Langefeld, Carl DAinsworth, Hannah CCunninghame Graham, Deborah SKelly, Jennifer AComeau, Mary EMarion, Miranda CHoward, Timothy DRamos, Paula SCroker, Jennifer AMorris, David LSandling, Johanna KAlmlöf, Jonas CarlssonAcevedo-Vásquez, Eduardo MAlarcón, Graciela SBabini, Alejandra MBaca, VicenteBengtsson, Anders ABerbotto, Guillermo ABijl, MarcBrown, Elizabeth EBrunner, Hermine ICardiel, Mario HCatoggio, LuisCervera, RicardCucho-Venegas, Jorge MDahlqvist, Solbritt RantapääD'Alfonso, SandraDa Silva, Berta Martinsde la Rúa Figueroa, IñigoDoria, AndreaEdberg, Jeffrey CEndreffy, EmőkeEsquivel-Valerio, Jorge AFortin, Paul RFreedman, Barry IFrostegård, JohanGarcía, Mercedes Ade la Torre, Ignacio GarcíaGilkeson, Gary SGladman, Dafna DGunnarsson, IvaGuthridge, Joel MHuggins, Jennifer LJames, Judith AKallenberg, Cees G MKamen, Diane LKarp, David RKaufman, Kenneth MKottyan, Leah CKovács, LászlóLaustrup, HelleLauwerys, Bernard RLi, Quan-ZhenMaradiaga-Ceceña, Marco AMartín, JavierMcCune, Joseph MMcWilliams, David RMerrill, Joan TMiranda, PedroMoctezuma, José FNath, Swapan KNiewold, Timothy BOrozco, LorenaOrtego-Centeno, NorbertoPetri, MichellePineau, Christian APons-Estel, Bernardo APope, JanetRaj, PrithviRamsey-Goldman, RosalindReveille, John DRussell, Laurie PSabio, José MAguilar-Salinas, Carlos AScherbarth, Hugo RScorza, RaffaellaSeldin, Michael FSjöwall, ChristopherSvenungsson, ElisabetThompson, Susan DToloza, Sergio M ATruedsson, LennartTusié-Luna, TeresaVasconcelos, CarlosVilá, Luis MWallace, Daniel JWeisman, Michael HWither, Joan EBhangale, TusharOksenberg, Jorge RRioux, John DGregersen, Peter KSyvänen, Ann-ChristineRönnblom, LarsCriswell, Lindsey AJacob, Chaim OSivils, Kathy LTsao, Betty PSchanberg, Laura EBehrens, Timothy WSilverman, Earl DAlarcón-Riquelme, Marta EKimberly, Robert PHarley, John BWakeland, Edward KGraham, Robert RGaffney, Patrick MVyse, Timothy J2023-01-252023-01-252017-07-17http://hdl.handle.net/10668/11414Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We identify 58 distinct non-HLA regions in EA, 9 in AA and 16 in HA (∼50% of these regions have multiple independent associations); these include 24 novel SLE regions (PenAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Age of OnsetAmerican Indian or Alaska NativeBlack PeopleCase-Control StudiesGenetic LoadHLA AntigensHispanic or LatinoHumansLogistic ModelsLupus Erythematosus, SystemicMultifactorial InheritanceMutagenesis, InsertionalPolymorphism, Single NucleotideSequence DeletionWhite Peopleresearch article28714469open access10.1038/ncomms160212041-1723PMC5520018https://www.nature.com/articles/ncomms16021.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520018/pdf