Loucera, CarlosPerez-Florido, JavierCasimiro-Soriguer, Carlos SOrtuño, Francisco MCarmona, RosarioBostelmann, GerritMartinez-Gonzalez, L JavierMuñoyerro-Muñiz, DoloresVillegas, RomanRodriguez-Baño, JesusRomero-Gomez, ManuelLorusso, NicolaGarcia-Leon, JavierNavarro-Mari, Jose MCamacho-Martinez, PedroMerino-Diaz, LauraSalazar, Adolfo deViñuela, LauraLepe, Jose AGarcia, FedericoDopazo, Joaquin2023-05-032023-05-032022-08-27Loucera C, Perez-Florido J, Casimiro-Soriguer CS, Ortuño FM, Carmona R, Bostelmann G, et al. Assessing the Impact of SARS-CoV-2 Lineages and Mutations on Patient Survival. Viruses. 2022 Aug 27;14(9):1893.http://hdl.handle.net/10668/21601More than two years into the COVID-19 pandemic, SARS-CoV-2 still remains a global public health problem. Successive waves of infection have produced new SARS-CoV-2 variants with new mutations for which the impact on COVID-19 severity and patient survival is uncertain. A total of 764 SARS-CoV-2 genomes, sequenced from COVID-19 patients, hospitalized from 19th February 2020 to 30 April 2021, along with their clinical data, were used for survival analysis. A significant association of B.1.1.7, the alpha lineage, with patient mortality (log hazard ratio (LHR) = 0.51, C.I. = [0.14,0.88]) was found upon adjustment by all the covariates known to affect COVID-19 prognosis. Moreover, survival analysis of mutations in the SARS-CoV-2 genome revealed 27 of them were significantly associated with higher mortality of patients. Most of these mutations were located in the genes coding for the S, ORF8, and N proteins. This study illustrates how a combination of genomic and clinical data can provide solid evidence for the impact of viral lineage on patient survival.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/COVID-19SARS-CoV-2phylogenysurvivalvirus genomeCOVID-19Genome, ViralHumansMutationPandemicsPhylogenySARS-CoV-2research article36146700open accessPacientesMutaciónAnálisis de supervivenciaMortalidadSobrevidaGenomaProteínasPronósticoInfeccionesCodificación Clínica10.3390/v140918931999-4915PMC9500738https://www.mdpi.com/1999-4915/14/9/1893/pdf?version=1661590117https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500738/pdf