Sánchez-Díaz, ManuelLópez-Delgado, DavidMontero-Vílchez, TrinidadSalvador-Rodríguez, LuisMolina-Leyva, AlejandroTercedor-Sánchez, JesúsArias-Santiago, Salvador2022-09-122022-09-122021-09-20Sánchez-Díaz M, López-Delgado D, Montero-Vílchez T, Salvador-Rodríguez L, Molina-Leyva A, Tercedor-Sánchez J, et al. Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects. J Clin Med. 2021 Sep 20;10(18):4257http://hdl.handle.net/10668/4041Oral minoxidil is an approved treatment for high blood pressure which is also used as an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric population is limited. A retrospective case series study of paediatric patients with history of systemic minoxidil intake due to contaminated sets of omeprazole was performed to describe side effects of high dose oral minoxidil intake in children. Twenty patients aged between 2 months and 13 years joined the study. They had received high doses of oral minoxidil (mean dose 0.90 mg/kg/day) during a mean time of 38.3 days. Hypertrichosis appeared in 65%, with a mean latency time of 24.31 days. Treatment time was associated with the appearance of hypertrichosis (p < 0.05). Most common initial zone of hypertrichosis was the face. Systemic effects developed in 15%, with no cases of severe disorders. The present study shows a novel insight into the side effects of high doses of oral minoxidil in children.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/MinoxidilHypertrichosisAlopeciaChildrenHipertricosisNiñoPacientesMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Persons::Persons::Age Groups::ChildMedical Subject Headings::Persons::Persons::Age Groups::InfantMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines::MinoxidilMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Prescriptions::Off-Label UseMedical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::HypertrichosisMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective StudiesMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::HypertensionMedical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::Hypotrichosis::AlopeciaMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfoxides::2-Pyridinylmethylsulfinylbenzimidazoles::Omeprazoleresearch article34575367open access10.3390/jcm101842572077-0383PMC8470761