López-Pousa, AMartin Broto, JMartinez Trufero, JSevilla, IValverde, CAlvarez, RCarrasco Alvarez, J ACruz Jurado, JHindi, NGarcia Del Muro, X2023-01-252023-01-252016http://hdl.handle.net/10668/10655Soft-tissue sarcomas are uncommon and heterogeneous tumors of mesenchymal origin. A soft-tissue mass that is increasing in size, greater than 5 cm, or located under deep fascia are criteria for suspicion of sarcoma. Diagnosis, treatment, and management should preferably be performed by a multidisciplinary team in reference centers. MRI and lung CT scan are mandatory for local and distant assessment. A biopsy indicating histological type and grade is needed previous to the treatment. Wide surgical resection with tumor-free tissue margin is the primary treatment for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not likely of being improved with reexcision. Neoadjuvant and adjuvant chemotherapy improve survival in selected cases, usually in high-grade sarcomas of the extremities. In the case of metastatic disease, patients with exclusive lung metastasis could be considered for surgery. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. New drugs have shown activity in second-line therapy and in specific histological subtypes.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Clinical guidelinesSarcomaSoft-tissue tumorsUncommon tumorsHumansNeoplasm GradingNeoplasm MetastasisPractice Guidelines as TopicSarcomaSoft Tissue NeoplasmsSpainresearch article27905051open access10.1007/s12094-016-1574-11699-3055PMC5138243https://link.springer.com/content/pdf/10.1007%2Fs12094-016-1574-1.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138243/pdf