Gu, ShoujunOlszewski, RafalNelson, LaceyGallego-Martinez, AlvaroLopez-Escamez, Jose AntonioHoa, Michael2022-09-262022-09-262021-02-05Gu S, Olszewski R, Nelson L, Gallego-Martinez A, Lopez-Escamez JA, Hoa M. Identification of Potential Meniere's Disease Targets in the Adult Stria Vascularis. Front Neurol. 2021 Feb 5;12:630561.http://hdl.handle.net/10668/4144The stria vascularis generates the endocochlear potential and is involved in processes that underlie ionic homeostasis in the cochlear endolymph, both which play essential roles in hearing. The histological hallmark of Meniere's disease (MD) is endolymphatic hydrops, which refers to the bulging or expansion of the scala media, which is the endolymph-containing compartment of the cochlea. This histologic hallmark suggests that processes that disrupt ion homeostasis or potentially endocochlear potential may underlie MD. While treatments exist for vestibular symptoms related to MD, effective therapies for hearing fluctuation and hearing loss seen in MD remain elusive. Understanding the potential cell types involved in MD may inform the creation of disease mouse models and provide insight into underlying mechanisms and potential therapeutic targets. For these reasons, we compare published datasets related to MD in humans with our previously published adult mouse stria vascularis single-cell and single-nucleus RNA-Seq datasets to implicate potentially involved stria vascularis (SV) cell types in MD. Finally, we provide support for these implicated cell types by demonstrating co-expression of select candidate genes for MD within SV cell types.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Stria vascularisSingle-cell, nucleusRNA-seqMeniere’s, ion homeostasisMeniere’s diseaseEndolymphEndolymphatic HydropsCochleaHearing LossSystematic ReviewHomeostasisEstría vascularEnfermedad de MeniereEndolinfaHidropesía endolinfáticaCócleaPérdida auditivaRevisión sistemáticaMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::MiceMedical Subject Headings::Organisms::Eukaryota::AnimalsMedical Subject Headings::Anatomy::Sense Organs::Ear::Ear, Inner::Cochlea::Cochlear Duct::Stria VascularisMedical Subject Headings::Anatomy::Fluids and Secretions::Body Fluids::Extracellular Fluid::Labyrinthine Fluids::EndolymphMedical Subject Headings::Anatomy::Sense Organs::Ear::Ear, Inner::CochleaMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Sensation::HearingMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Hearing LossMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Labyrinth Diseases::Endolymphatic HydropsMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Homeostasisreview article33613436open access10.3389/fneur.2021.6305611664-2295PMC7894210