Ortega-Molina, J. M.Solans-Perez de Larraya, A.Salgado-Miranda, A.Jerez-Calero, A.Uberos-Fernandez, J.Gonzalez Ramirez, A. R.Garcia-Serrano, J. L.2023-02-122023-02-122017-08-012008-2142http://hdl.handle.net/10668/19383Objectives: To assess risk factors of retinopathy of prematurity leading to delayed retinal vascularization in the first stage of ROP.Methods: Aretrospective study (2000 - 2016) was performed in 275 infants who were born at a gestational age of = 10 days) lead to delayed retinal vascularization of 1.74, 1.58, 1.17, and 1.11 disc diameters and of 3.35, 3.04, 2.25 and 2.13 weeks respectively. Delayed retinal vascular development was less than 1 disc diameter in other factors such as HS-PDA, sepsis, degree of hyaline membrane >= III, cerebral hemorrhage, birth weight (every 100 g less), gestational age (every week less), postnatal weight gain (every 1 g less/day) and cerebral hemorrhage. However, since these factors are quantitative (birth weight, gestational age and postnatal weight gain), the greater the adverse effect, the greater the delay will be.Conclusions: Intrauterine fetal demise of one twin, apnea, exchange tranfusion and intubation days (>= 10 days) lead to delayed retinal vascular development more than 1 disc diameter at 4 -6 weeks of postnatal life.enAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/Retinopathy of PrematurityAngiogenesis Modulating AgentsRisk FactorsPatent ductus-arteriosusInfantsPathophysiologyUpdateLiferesearch articleopen access10.5812/ijp.76422008-2150http://ijp.neoscriber.org/cdn/dl/7add74e6-adec-11e7-8193-43389d6e3fd6416096000007