Mundo-López, AntonioOcón-Hernández, OlgaSan-Sebastián, Ainhoa P.Galiano-Castillo, NoeliaRodríguez-Pérez, OlgaArroyo-Luque, María S.Arroyo-Morales, ManuelCantarero-Villanueva, IreneFernández-Lao, CarolinaArtacho-Cordón, Francisco2022-07-262022-07-262020-05-28Mundo-López A, Ocón-Hernández O, San-Sebastián AP, Galiano-Castillo N, Rodríguez-Pérez O, Arroyo-Luque MS, et al. Contribution of Chronic Fatigue to Psychosocial Status and Quality of Life in Spanish Women Diagnosed with Endometriosis. Int J Environ Res Public Health. 2020 May 28;17(11):38311661-7827http://hdl.handle.net/10668/3830Aim: To analyze the levels of chronic fatigue in Spanish women with endometriosis and its relationship with their psychosocial status and quality of life (QoL). Methods: A total of 230 Spanish women with a clinical diagnosis of endometriosis were recruited. Chronic fatigue (Piper Fatigue Scale) and pelvic pain (Numeric Rating Scale) were evaluated. An on-line battery of validated scales was used to assess psychosocial status [Hospital Anxiety and Depression Scale, Scale for Mood Assessment, Pain Catastrophizing Scale, Pittsburgh Sleep Quality Index, Gastrointestinal Quality of Life Index, Female Sexual Function Index and Medical Outcomes Study-Social Support Survey] and QoL [Endometriosis-Health Profile questionnaire-30]. Associations between fatigue and both psychosocial and QoL outcomes were explored through multivariate regression models. Results: One-third and one-half of women showed moderate and severe fatigue, respectively. Fatigue was associated with higher anxiety and depression, poorer sleep quality, poorer sexual functioning, worse gastrointestinal health, higher catastrophizing thoughts, higher anger/hostility scores and lower QoL (p-values < 0.050). Moreover, fatigue and catastrophizing thoughts showed a mediating effect on the association between pelvic pain and QoL. Conclusion: This work reveals the important role of fatigue in the association between pain, psychosocial status, and QoL of Spanish women with endometriosis.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Chronic fatigueEndometriosisPsychosocial statusQuality of lifeSurveys and questionnairesSíndrome de fatiga crónicaCalidad de vidaDepresiónEncuestas y cuestionariosMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::AnxietyMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety::CatastrophizationMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::DepressionMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::EndometriosisMedical Subject Headings::Check Tags::FemaleMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::HumansMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Pain::Pelvic PainMedical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of LifeMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::SpainMedical Subject Headings::Diseases::Nervous System Diseases::Neuromuscular Diseases::Fatigue Syndrome, ChronicMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::HostilityMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::AngerMedical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spainresearch article32481648open access10.3390/ijerph171138311660-4601PMC7312817