Dominguez, A.Soldevila, N.Toledo, D.Godoy, P.Espejo, E.Fernandez, M. A.Mayoral, J. M.Castilla, J.Egurrola, M.Tamames, S.Astray, J.Morales-Suarez-Varela, M.Project PI12-020792023-02-122023-02-122017-08-241560-7917http://hdl.handle.net/10668/19203Influenza vaccination may limit the impact of influenza in the community. The aim of this study was to assess the effectiveness of influenza vaccination in preventing hospitalisation in individuals aged >= 65 years in Spain. A multicentre case-control study was conducted in 20 Spanish hospitals during 2013/14 and 2014/15. Patients aged >= 65 years who were hospitalised with laboratory-confirmed influenza were matched with controls according to sex, age and date of hospitalisation. Adjusted vaccine effectiveness (VE) was calculated by multivariate conditional logistic regression. A total of 728 cases and 1,826 matched controls were included in the study. Overall VE was 36% (95% confidence interval (CI): 22-47). VE was 51% (95% CI: 15-71) in patients without high-risk medical conditions and 30% (95% CI: 14-44) in patients with them. VE was 39% (95% CI: 20-53) in patients aged 65-79 years and 34% (95% CI: 11-51) in patients aged >= 80 years, and was greater against the influenza A(H1N1) pdm0(9) subtype than the A(H3N2) subtype. Influenza vaccination was effective in preventing hospitalisations of elderly individuals.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Laboratory-confirmed influenzaScreening methodUnited-statesNew-zealandPopulationAucklandNavarreImpactresearch articleopen access10.2807/1560-7917.ES.2017.22.34.30602https://doi.org/10.2807/1560-7917.es.2017.22.34.30602408438400003