Montes Castillo, María CristinaMartínez Ramírez, María JoséSoriano Arroyo, RubénPrieto Gomez, IsabelSegarra Robles, Ana BelénGarrido-Martínez, MacarenaSantiago-Fernández, PiedadDelgado Rodríguez, Miguel2023-01-252023-01-252019-09-20http://hdl.handle.net/10668/14526Osteoporosis results from an imbalance in bone remodeling, which is known to follow a circadian rhythm determined by a functional relationship between intestine and bone tissue. Specific intestinal peptides have been identified as mediators. Glucagon-like peptide 1 and glucagon-like peptide 2, have been associated with bone health. Our main objective was to determine whether postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2 and dipeptidyl-peptidase 4 activity, are associated with osteoporosis in non-diabetic postmenopausal women. We studied non-diabetic postmenopausal women with osteoporosis diagnosed by dual-energy X-ray absorptiometry (cases, n = 43) and age-matched (±1 yr) controls without osteoporosis or a history of osteoporotic fracture (n = 43). We measured postprandial plasma levels of glucagon-like peptide 1, glucagon-like peptide 2, and dipeptidyl-peptidase 4 activity, bone mineral density, and baseline levels of bone remodeling markers and analyzed the food intake using a food-frequency questionnaire. Postprandial glucagon-like peptide 1 values were lower (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Absorptiometry, PhotonBone DensityCase-Control StudiesDipeptidyl Peptidase 4EatingFemaleGlucagon-Like Peptide 1Glucagon-Like Peptide 2HumansMiddle AgedOsteoporosis, PostmenopausalPostprandial Periodresearch article31541189open access10.1038/s41598-019-50117-z2045-2322PMC6754449https://www.nature.com/articles/s41598-019-50117-z.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754449/pdf