Quiles, José LRivas-García, LorenzoVarela-López, AlfonsoLlopis, JuanBattino, MaurizioSánchez-González, Cristina2023-02-092023-02-092020-08-22http://hdl.handle.net/10668/16142The repositioning of therapeutic agents already approved by the regulatory agencies for the use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of using molecules derived from foods, whether nutrients or not, is of great importance, also because of their immediate therapeutic applicability. Candidates for these natural therapies against COVID-19 should show certain effects, such as restoring mitochondrial function and cellular redox balance. This would allow reducing the susceptibility of risk groups and the cascade of events after SARS-CoV-2 infection, responsible for the clinical picture, triggered by the imbalance towards oxidation, inflammation, and cytokine storm. Possible strategies to follow through the use of substances of food origin would include: a) the promotion of mitophagy to remove dysfunctional mitochondria originating from free radicals, proton imbalance and virus evasion of the immune system; b) the administration of transition metals whose redox activity would lead to their own oxidation and the consequent generation of a reduced environment, which would normalize the oxidative state and the intracellular pH; c) the administration of molecules with demonstrated antioxidant capacity; d) the administration of compounds with anti-inflammatory and vasodilatory activity; e) the administration of immunomodulatory compounds.enCurcuminPolyphenolsVitamin CVitamin DZincAntioxidantsBetacoronavirusCOVID-19Coronavirus InfectionsFunctional FoodHumansMitochondriaNutrientsPandemicsPneumonia, ViralSARS-CoV-2research article32835682open access10.1016/j.envres.2020.1100531096-0953PMC7442575https://doi.org/10.1016/j.envres.2020.110053https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7442575/pdf