Molina-Fernández, ÍñigoLeuermann, JonasOrtega-Moñux, AlejandroWangüemert-Pérez, J. GonzaloHalir, Robert2021-06-172021-06-172019-04-29Molina-Fernández Í, Leuermann J, Ortega-Moñux A, Wangüemert-Pérez JG, Halir R. Fundamental limit of detection of photonic biosensors with coherent phase read-out. Opt Express. 2019 Apr 29;27(9):12616-12629.http://hdl.handle.net/10668/3373Photonic biosensors offer label-free detection of biomolecules for applications ranging from clinical diagnosis to food quality monitoring. Both sensors based on Mach-Zehnder interferometers and ring resonators are widely used, but are usually read-out using different schemes, making a direct comparison of their fundamental limit of detection challenging. A coherent detection scheme, adapted from optical communication systems, has been recently shown to achieve excellent detection limits, using a simple fixed-wavelength source. Here we present, for the first time, a theoretical model to determine the fundamental limit of detection of such a coherent read-out system, for both interferometric and resonant sensors. Based on this analysis, we provide guidelines for sensor optimization in the presence of optical losses and show that interferometric sensors are preferable over resonant structures when the sensor size is not limited by the available sample volume.enTécnicas biosensiblesLímite de detecciónInterferometríaDispositivos ópticosFotonesModelos teóricosBiosensing techniquesLimit of detectionInterferometryOptical devicesPhotonsModels, theoreticalMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Biosensing TechniquesMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Sensitivity and Specificity::Limit of DetectionMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::InterferometryMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Optical DevicesMedical Subject Headings::Phenomena and Processes::Physical Phenomena::Optical Phenomena::Light::PhotonsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoreticalresearch article31052800Acceso abierto10.1364/OE.27.0126161094-4087