Beaumont, JavierLópez, BegoñaRavassa, SusanaHermida, NereaSan José, GorkaGallego, IdoiaValencia, FélixGómez-Doblas, Juan Joséde Teresa, EduardoDíez, JavierGonzález, Arantxa2023-01-252023-01-252017-01-16http://hdl.handle.net/10668/10778This study analyzed the potential associations of 7 myocardial fibrosis-related microRNAs with the quality of the collagen network (e.g., the degree of collagen fibril cross-linking or CCL) and the enzyme lysyl oxidase (LOX) responsible for CCL in 28 patients with severe aortic stenosis (AS) of whom 46% had a diagnosis of chronic heart failure (HF). MicroRNA expression was analyzed in myocardial and blood samples. From the studied microRNAs only miR-19b presented a direct correlation (p enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/AgedAortic Valve StenosisBiomarkersCollagenComorbidityEchocardiographyFemaleFibrosisGene Expression RegulationHeart FailureHeart Function TestsHumansMaleMicroRNAsMyocardiumRNA InterferenceTranscriptomeresearch article28091585open access10.1038/srep406962045-2322PMC5238428https://www.nature.com/articles/srep40696.pdfhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238428/pdf