Herrera-Hidalgo, Laurade Alarcón, ArístidesLópez-Cortes, Luis E.Luque-Márquez, RafaelLópez-Cortes, Luis F.Gutiérrez-Valencia, AliciaGil-Navarro, María V.2022-06-272022-06-272020-09-30Herrera-Hidalgo L, de Alarcón A, López-Cortes LE, Luque-Márquez R, López-Cortes LF, Gutiérrez-Valencia A, et al. Enterococcus faecalis Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives. Antibiotics. 2020 Sep 30;9(10):657http://hdl.handle.net/10668/3712The selection of the best alternative for Enterococcus faecalis infective endocarditis (IE) continuation treatment in the outpatient setting is still challenging. Three databases were searched, reporting antibiotic therapies against E. faecalis IE in or suitable for the outpatient setting. Articles the results of which were identified by species and treatment regimen were included. The quality of the studies was assessed accordingly with the study design. Data were extracted and synthesized narratively. In total, 18 studies were included. The treatment regimens reported were classified regarding the main antibiotic used as regimen, based on Aminoglycosides, dual β-lactam, teicoplanin, daptomycin or dalbavancin or oral therapy. The regimens based on aminoglycosides and dual β-lactam combinations are the treatment alternatives which gather more evidence regarding their efficacy. Dual β-lactam is the preferred option for high level aminoglycoside resistance strains, and for to its reduced nephrotoxicity, while its adaptation to the outpatient setting has been poorly documented. Less evidence supports the remaining alternatives, but many of them have been successfully adapted to outpatient care. Teicoplanin and dalbavancin as well as oral therapy seem promising. Our work provides an extensive examination of the potential alternatives to E. faecalis IE useful for outpatient care. However, the insufficient evidence hampers the attempt to give a general recommendation.enAtribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/Enterococcus faecalisInfective endocarditisOutpatient treatmentOutpatient parenteral antibiotic treatment (OPAT)Systematic reviewTreatment alternativesEndocarditisAtención ambulatoriaRevisión sistemáticaAminoglicósidosBeta-LactamasMedical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Enterococcaceae::Enterococcus::Enterococcus faecalisMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Ambulatory CareMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial AgentsMedical Subject Headings::Persons::Persons::Patients::OutpatientsMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycosides::AminoglycosidesMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-LactamsMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeuticsreview article33007853open access10.3390/antibiotics91006572079-6382PMC7600219